Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate (Q41064013)

26 September 2017

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate (English)

1 reference

26 September 2017

1 reference

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660692%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Quentin Glenadel

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660692%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Catherine A Evans

1

1 reference

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1 June 2020

Tao Liu

2

1 reference

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1 June 2020

André Lescarbeau

3

1 reference

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1 June 2020

Somarajan J Nair

4

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1 June 2020

Louis Grenier

5

1 reference

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1 June 2020

Thomas Tibbitts

8

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1 June 2020

Ann M Rowley

9

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1 June 2020

Jonathan P DiNitto

10

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1 June 2020

Erin E Brophy

11

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1 June 2020

Erin L O'Hearn

12

1 reference

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1 June 2020

Janid A Ali

13

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1 June 2020

David G Winkler

14

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1 June 2020

Stanley I Goldstein

15

1 reference

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1 June 2020

Patrick O'Hearn

16

1 reference

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1 June 2020

Christian M Martin

17

1 reference

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1 June 2020

Jennifer G Hoyt

18

1 reference

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1 June 2020

John R Soglia

19

1 reference

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1 June 2020

Culver Cheung

20

1 reference

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1 June 2020

Melissa M Pink

21

1 reference

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1 June 2020

Jennifer L Proctor

22

1 reference

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1 June 2020

Vito J Palombella

23

1 reference

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1 June 2020

Martin R Tremblay

24

1 reference

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1 June 2020

Alfredo C Castro

25

1 reference

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1 June 2020

publication date

22 July 2016

1 reference

ACS Medicinal Chemistry Letters

26 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660692%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

7

1 reference

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1 June 2020

issue

9

1 reference

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1 June 2020

page(s)

862-867

1 reference

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Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

1 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

PI3K signalling in inflammation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Macrophage regulation of tumor responses to anticancer therapies

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

The phosphoinositide 3-kinase pathway

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5018865

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27660692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.6B00238

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660692%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660692%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference