Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. (Q35129307)

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English	Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.	scientific article

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4 February 2020

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression (English)

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4 February 2020

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toll-like receptor

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

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GOA release 2020-03-11

Phosphoinositide-3-kinase regulatory subunit 5

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GOA release 2020-03-11

Michael C Schmid

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Judith A. Varner

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Philippe Foubert

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Philippe Foubert

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Christie J Avraamides

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Holly C Dippold

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Lesley G Ellies

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Lissette M Acevedo

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Joan R E Manglicmot

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Xiaodan Song

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Wolfgang Wrasidlo

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Sara L Blair

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Mark H Ginsberg

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David A Cheresh

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publication date

1 June 2011

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715-727

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6

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4 February 2020

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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13 July 2018

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

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13 July 2018

Development of phosphoinositide-3 kinase pathway inhibitors for advanced cancer

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13 July 2018

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

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13 July 2018

The emerging mechanisms of isoform-specific PI3K signalling

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13 July 2018

Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis

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Immunity, Inflammation, and Cancer

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Chemokines and chemokine receptors: new insights into cancer-related inflammation.

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TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB

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13 July 2018

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

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Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

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13 July 2018

Myeloid-derived suppressor cells as regulators of the immune system

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

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13 July 2018

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

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H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors

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13 July 2018

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

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13 July 2018

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

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Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

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Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury

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Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

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Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

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27 September 2018

Interaction of Ras with phosphoinositide 3-kinase gamma

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

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16 November 2018

Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21665146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21665146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CCR.2011.04.016

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4 February 2020

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4 February 2020

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4 February 2020

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