The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain (Q40995235)

25 September 2017

The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain (English)

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25 September 2017

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25 September 2017

L Hennighausen

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author name string

A Lischke

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25 September 2017

S Brändlein

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25 September 2017

S Berchtold

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25 September 2017

W Kammer

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25 September 2017

W Sebald

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25 September 2017

B Groner

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25 September 2017

X Liu

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25 September 2017

K Friedrich

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25 September 2017

language of work or name

English

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publication date

1 November 1998

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Journal of Biological Chemistry

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25 September 2017

273

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31222-31229

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25 September 2017

47

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Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

25 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

IL-4 and IL-13 receptors: are they one and the same?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Mutational analysis of a critical signaling domain of the human interleukin 4 receptor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Interleukin 4 signals through two related pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Essential role of Stat6 in IL-4 signalling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Signaling through the hematopoietic cytokine receptors.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Different human interleukin-4 mutants preferentially activate human or murine common receptor gamma chain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

A family of cytokine-inducible inhibitors of signalling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31222

21 January 2018

Identifiers

DOI

10.1074/JBC.273.47.31222

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25 September 2017

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