Detection of DNA modifications by the 32P-postlabelling assay (Q40885183)

24 September 2017

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title

Detection of DNA modifications by the 32P-postlabelling assay (English)

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24 September 2017

1

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PubMed ID

9288880

24 September 2017

language of work or name

English

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publication date

1 August 1997

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24 September 2017

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24 September 2017

378

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24 September 2017

1-2

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24 September 2017

1-12

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32P-labeling test for DNA damage

24 September 2017

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32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.

7 January 2021

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Human biomonitoring and the 32P-postlabeling assay

7 January 2021

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32P-postlabeling methods for DNA adduct detection: overview and critical evaluation

7 January 2021

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A new sensitive 32P-postlabeling assay based on the specific enzymatic conversion of bulky DNA lesions to radiolabeled dinucleotides and nucleoside 5'-monophosphates.

7 January 2021

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Fluoranthene-DNA adducts: identification and quantification by an HPLC-32P-postlabeling method

7 January 2021

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32P-post-labelling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct pattern simplification

7 January 2021

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32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.

7 January 2021

1 reference

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Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

7 January 2021

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HPLC enrichment of hydrophobic DNA--carcinogen adducts for enhanced sensitivity of 32P-postlabeling analysis.

7 January 2021

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DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5- f]quinoline at the C-8 and N2 atoms of guanine

7 January 2021

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Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes

7 January 2021

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Immunoaffinity purification combined with 32P-postlabelling for the detection of O6-methylguanine in DNA from human tissues

7 January 2021

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1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling

7 January 2021

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Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alphaC)

7 January 2021

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Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice fed a high omega-3 fatty acid diet.

7 January 2021

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Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene

7 January 2021

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Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene.

7 January 2021

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Covalent binding of dibenzpyrenes and benzo[a]Pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin

7 January 2021

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Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene

7 January 2021

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Formation and persistence of benzo[a]pyrene-DNA adducts in mouse epidermis in vivo: importance of adduct conformation

7 January 2021

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Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

7 January 2021

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Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.

7 January 2021

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Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.

7 January 2021

1 reference

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Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.

7 January 2021

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Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

7 January 2021

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Cyproterone acetate is an integral part of hepatic DNA adducts induced by this steroidal drug.

7 January 2021

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Identification of 3 alpha-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabolites to form DNA adducts in vitro.

7 January 2021

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32P-postlabelling of 7-methyl-dGMP ring-opened 7-methyl-dGMP and platinated dGpdG

7 January 2021

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32P-postlabeling of N-7, N2 and O6 2'-deoxyguanosine 3'-monophosphate adducts of styrene oxide.

7 January 2021

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DNA adducts from chemotherapeutic agents

7 January 2021

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Formation of a phosphoramide mustard-nucleotide adduct that is not by alkylation at the N7 position of guanine

7 January 2021

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32P-post-labelling analysis of DNA adducts formed by antitumor 1-nitro-9-aminoacridines with DNA of HeLa S3 cells

7 January 2021

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Measurement by 32P-postlabelling of 7-methylguanine levels in white blood cell DNA of healthy individuals and cancer patients treated with dacarbazine and procarbazine. Human data and method development for 7-alkylguanines

7 January 2021

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Detection of platinum-DNA adducts by 32P-postlabelling

7 January 2021

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Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin.

7 January 2021

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Covalent binding of components of coal-tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application

7 January 2021

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Correlation of mutagenic potencies of various petroleum oils and oil coal tar mixtures with DNA adduct levels in vitro.

7 January 2021

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DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke.

7 January 2021

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DNA adducts in human environmentally exposed to aromatic compounds in an industrial area of Poland

7 January 2021

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Seasonal variation of aromatic DNA adducts in human lymphocytes and granulocytes.

7 January 2021

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Air pollution exposure-DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses

7 January 2021

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32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures.

7 January 2021

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DNA adducts, detected by 32P-postlabelling, in DNA treated in vitro with bile from patients with familial adenomatous polyposis and from unaffected controls

7 January 2021

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DNA adducts, detected by 32P-postlabelling, in the foregut of patients with familial adenomatous polyposis and in unaffected controls

7 January 2021

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The use of 32P-postlabelling in studies of the nature and origin of DNA adducts formed by bile from patients with familial adenomatous polyposis and from normal patients

7 January 2021

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The application of the 32P-postlabelling assay to aquatic biomonitoring

7 January 2021

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32P-postlabeling determination of DNA adducts in the earthworm Lumbricus terrestris exposed to PAH-contaminated soils

7 January 2021

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Detection by 32P-postlabeling of thymidine glycol in gamma-irradiated DNA.

7 January 2021

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32P-postlabeling detection of thymine glycols: evaluation of adduct recoveries after enhancement with affinity chromatography, nuclease P1, nuclease S1, and polynucleotide kinase.

7 January 2021

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Phosphorus-32-postlabeling detection of radiation-induced DNA damage: identification and estimation of thymine glycols and phosphoglycolate termini

7 January 2021

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Response of phage T4 polynucleotide kinase toward dinucleotides containing apurinic sites: design of a 32P-postlabeling assay for apurinic sites in DNA.

7 January 2021

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Use of a postlabelling assay to examine the removal of radiation-induced DNA lesions by purified enzymes and human cell extracts

7 January 2021

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32P-postlabelling approaches for the detection of 8-oxo-2'-deoxyguanosine-3'-monophosphate in DNA.

7 January 2021

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Exposure of mammalian cell cultures to benzo[a]pyrene and light results in oxidative DNA damage as measured by 8-hydroxydeoxyguanosine formation

7 January 2021

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Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA.

7 January 2021

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Production of 8-hydroxy-2'-deoxguanosine in DNA by microsomal activation of tamoxifen and 4-hydroxytamoxifen

7 January 2021

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Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation

7 January 2021

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Sensitive detection of 8-hydroxy-2'deoxyguanosine in DNA by 32P-postlabeling assay and the basal levels in rat tissues

7 January 2021

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Bulky adducts detected by 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds

7 January 2021

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Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system

7 January 2021

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Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence.

7 January 2021

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Bulky DNA-adduct formation induced by Ni(II) in vitro and in vivo as assayed by 32P-postlabeling

7 January 2021

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Intensification and depletion of specific bulky renal DNA adducts (I-compounds) following exposure of male F344 rats to the renal carcinogen ferric nitrilotriacetate (Fe-NTA)

7 January 2021

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Generation of Putative Intrastrand Cross-Links and Strand Breaks in DNA by Transition Metal Ion-Mediated Oxygen Radical Attack

7 January 2021

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Formation, detection, and role in carcinogenesis of ethenobases in DNA.

7 January 2021

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HPLC-32P-postlabelling analysis of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine

7 January 2021

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Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition.

7 January 2021

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Organ-specific oxidative DNA damage associated with normal birth in rats

7 January 2021

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Enzyme-mediated phosphorylation of polycyclic hydrocarbon metabolites: detection of non-adduct compounds in the 32P-postlabelling assay.

7 January 2021

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32P-postlabeling of bile components: bulky adduct-like behavior in polyethyleneimine-cellulose thin layer chromatography.

7 January 2021

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Appearance of artefacts when using 32P-postlabelling to investigate DNA adduct formation by bile acids in vitro: lack of evidence for covalent binding.

7 January 2021

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Altered fidelity of a nucleic acid modifying enzyme, T4 polynucleotide kinase, by safrole-induced DNA damage

7 January 2021

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Interlaboratory comparison of the 32P-postlabelling assay for aromatic DNA adducts in white blood cells of iron foundry workers

7 January 2021

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The use of benzo[a]pyrene diolepoxide-modified DNA standards for adduct quantification in 32P-postlabelling to assess exposure to polycyclic aromatic hydrocarbons: application in a biomonitoring study

7 January 2021

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Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA.

7 January 2021

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Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation.

7 January 2021

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Optimization of an HPLC method for analyses of 32P-postlabeled DNA adducts

7 January 2021

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10.1016/S0027-5107(97)00092-4

7 January 2021

Identifiers

DOI

1 reference

24 September 2017

1 reference

PubMed ID

9288880