The Bcl-2 family and cell death regulation (Q40864371)

24 September 2017

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title

The Bcl-2 family and cell death regulation (English)

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24 September 2017

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2

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24 September 2017

Newton K

1

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24 September 2017

1 February 1998

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Current Opinion in Genetics & Development

24 September 2017

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24 September 2017

8

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24 September 2017

1

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24 September 2017

68-75

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

24 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

An evolutionary perspective on apoptosis.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Programmed cell death in animal development

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Apoptosis and its role in human disease

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Cell death: the significance of apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Programmed cell death in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Induction of apoptosis by the Bcl-2 homologue Bak

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

BID: a novel BH3 domain-only death agonist

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Interaction and regulation of subcellular localization of CED-4 by CED-9

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

RAIDD is a new 'death' adaptor molecule

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Role of CED-4 in the activation of CED-3.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 and Bax function independently to regulate cell death

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Channel formation by antiapoptotic protein Bcl-2.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Inhibition of Bax channel-forming activity by Bcl-2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Ultrastructural localization of bcl-2 protein

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980064-6

7 January 2021

10.1016/S0959-437X(98)80064-6

Identifiers

DOI

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24 September 2017

1 reference

PubMed ID

9529608