TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation (Q40854245)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27323823%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation (English)

1 reference

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14 March 2020

0 references

1

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14 March 2020

15

John Lunec

1 reference

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14 March 2020

author name string

Arman Esfandiari

2

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14 March 2020

Junfeng Liu

3

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14 March 2020

Xiaohong Lu

4

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14 March 2020

Claire Hutton

5

1 reference

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14 March 2020

Jennifer Jackson

6

1 reference

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14 March 2020

Karim Bennaceur

7

1 reference

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14 March 2020

Qing Xu

8

1 reference

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14 March 2020

Aditya Rao Makimanejavali

9

1 reference

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14 March 2020

Fabio Del Bello

10

1 reference

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14 March 2020

Alessandro Piergentili

11

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14 March 2020

David R Newell

12

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14 March 2020

Ian R Hardcastle

13

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14 March 2020

Roger J Griffin

14

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14 March 2020

language of work or name

English

0 references

publication date

1 July 2016

1 reference

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14 March 2020

1 reference

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14 March 2020

volume

7

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14 March 2020

issue

29

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14 March 2020

page(s)

46203-46218

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describes a project that uses

14 March 2020

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1 reference

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24 September 2017

1 reference

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Identifying the determinants of response to MDM2 inhibition.

24 September 2017

1 reference

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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

24 September 2017

1 reference

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Cancer drug resistance: an evolving paradigm

24 September 2017

1 reference

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Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.

24 September 2017

1 reference

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24 September 2017

1 reference

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Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

24 September 2017

1 reference

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Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.

24 September 2017

1 reference

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A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

24 September 2017

1 reference

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Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

24 September 2017

1 reference

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High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma

24 September 2017

1 reference

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Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

24 September 2017

1 reference

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Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.

24 September 2017

1 reference

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Targeting the MDM2-p53 interaction for cancer therapy

24 September 2017

1 reference

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

24 September 2017

1 reference

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse

24 September 2017

1 reference

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24 September 2017

1 reference

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24 September 2017

1 reference

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24 September 2017

1 reference

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24 September 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

24 September 2017

1 reference

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The role of p53 in determining sensitivity to radiotherapy

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Multidrug resistance in cancer: role of ATP-dependent transporters

24 September 2017

1 reference

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24 September 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216791

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

24 September 2017

1 reference

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p53, the cellular gatekeeper for growth and division

24 September 2017

1 reference

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New colorimetric cytotoxicity assay for anticancer-drug screening

24 September 2017

1 reference

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p53 mutations in human cancers

24 September 2017

1 reference

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Amplification of a gene encoding a p53-associated protein in human sarcomas

24 September 2017

1 reference

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p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells

24 September 2017

1 reference

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p53 Mutation and MDM2 amplification in human soft tissue sarcomas

15 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27323823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27323823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.10073

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27323823%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27323823%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference