Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction (Q40714420)

23 September 2017

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction (English)

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23 September 2017

Hongmei Peng

1

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23 September 2017

Zeyd Sarwar

2

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23 September 2017

Xiao-Ping Yang

3

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23 September 2017

Edward L Peterson

4

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23 September 2017

Jiang Xu

5

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23 September 2017

Branislava Janic

6

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23 September 2017

Nadia Rhaleb

7

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23 September 2017

Oscar A Carretero

8

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23 September 2017

Nour-Eddine Rhaleb

9

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23 September 2017

language of work or name

English

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publication date

20 July 2015

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23 September 2017

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23 September 2017

66

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23 September 2017

3

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23 September 2017

582-589

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Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction.

23 September 2017

1 reference

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Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension

25 September 2017

1 reference

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STAT6 and lung inflammation

25 September 2017

1 reference

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'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation

25 September 2017

1 reference

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Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.

25 September 2017

1 reference

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Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice

25 September 2017

1 reference

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CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

25 September 2017

1 reference

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Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart

25 September 2017

1 reference

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Cardiac mast cells: the centrepiece in adverse myocardial remodelling

25 September 2017

1 reference

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Alternative activation of macrophages: mechanism and functions

25 September 2017

1 reference

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Differential release of mast cell mediators and the pathogenesis of inflammation

25 September 2017

1 reference

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Immunological basis of systemic sclerosis

25 September 2017

1 reference

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The relationship between myocardial extracellular matrix remodeling and ventricular function

25 September 2017

1 reference

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Cytokines and cardiovascular disease

25 September 2017

1 reference

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The cardiac fibroblast: therapeutic target in myocardial remodeling and failure

25 September 2017

1 reference

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Cytokine-induced modulation of cardiac function

25 September 2017

1 reference

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Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart

25 September 2017

1 reference

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Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1.

25 September 2017

1 reference

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Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts

25 September 2017

1 reference

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IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo

25 September 2017

1 reference

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Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses

25 September 2017

1 reference

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Biological activity of IL-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptor

25 September 2017

1 reference

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Force generation among cells in the relaxing heart

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells

17 June 2018

1 reference

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Interleukin 4 is localized to and released by human mast cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway

19 August 2018

1 reference

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Nutrient intake and serum cytokine pattern in elderly people with heart failure

19 August 2018

1 reference

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Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin‐4: Analysis of the functional collagen promoter sequences

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Evidence for a role of mast cells in the evolution to congestive heart failure

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

Diastolic Heart Failure — No Time to Relax

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4685692

The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response

2 December 2018

1 reference

12 December 2020

A pro-fibrotic role for interleukin-4 in cardiac pressure overload

1 reference

12 December 2020

Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair

1 reference

12 December 2020

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1 reference

12 December 2020

The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly

1 reference

12 December 2020

[Interleukin-4 and cardiac fibrosis in patients with heart failure]

1 reference

12 December 2020

Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodeling

1 reference

12 December 2020

Differential gene expression in response to transforming growth factor-beta1 by fetal and postnatal dermal fibroblasts

1 reference

12 December 2020

Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells

1 reference

12 December 2020

Cardiac mast cells: implications for heart failure

1 reference

12 December 2020

10.1161/HYPERTENSIONAHA.115.05627

Identifiers

DOI

1 reference

23 September 2017

1 reference

23 September 2017

PubMed publication ID

26195478

1 reference