'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation (Q38106128)

28 August 2017

'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation (English)

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28 August 2017

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Wei-ping Zeng

1

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28 August 2017

1 September 2013

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28 August 2017

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28 August 2017

140

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28 August 2017

1

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28 August 2017

31-38

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Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites

28 August 2017

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T-cell subset regulation in atopy

21 January 2018

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

21 January 2018

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 January 2018

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The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation

21 January 2018

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Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

21 January 2018

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Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.

21 January 2018

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The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

21 January 2018

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Interchromosomal associations between alternatively expressed loci

21 January 2018

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Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.

21 January 2018

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The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

21 January 2018

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Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

21 January 2018

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Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite

21 January 2018

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MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

21 January 2018

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Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE

21 January 2018

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CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

21 January 2018

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Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

21 January 2018

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Interleukin 2 plays a central role in Th2 differentiation.

21 January 2018

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Transcriptional regulation by STAT6.

21 January 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

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Essential role of Stat6 in IL-4 signalling

21 January 2018

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Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor.

21 January 2018

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Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human

21 January 2018

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

21 January 2018

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Th2 differentiation is unaffected by Jagged2 expression on dendritic cells

21 January 2018

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

21 January 2018

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Notch1 expression on T cells is not required for CD4+ T helper differentiation

21 January 2018

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Notch signalling: a simple pathway becomes complex

21 January 2018

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation

21 January 2018

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Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

21 January 2018

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Notch signaling is an important regulator of type 2 immunity.

21 January 2018

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Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.

21 January 2018

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GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

21 January 2018

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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

21 January 2018

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GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

21 January 2018

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Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

21 January 2018

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Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation

21 January 2018

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Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

21 January 2018

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Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation

21 January 2018

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Basal chromatin modification at the IL-4 gene in helper T cells

21 January 2018

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The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells.

21 January 2018

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Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production

21 January 2018

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

21 January 2018

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Demethylation of a specific hypersensitive site in the Th2 locus control region

21 January 2018

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Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression

21 January 2018

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Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.

21 January 2018

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GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

21 January 2018

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A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

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Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation

21 January 2018

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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

21 January 2018

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Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells.

21 January 2018

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Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma

21 January 2018

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Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

21 January 2018

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CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus

21 January 2018

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Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma

21 January 2018

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Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses

21 January 2018

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ROG, repressor of GATA, regulates the expression of cytokine genes

21 January 2018

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Deletion of a coordinate regulator of type 2 cytokine expression in mice

21 January 2018

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Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

21 January 2018

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Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

21 January 2018

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

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The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

21 January 2018

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NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

21 January 2018

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Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells.

21 January 2018

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The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

21 January 2018

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

21 January 2018

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NF-AT-Driven interleukin-4 transcription potentiated by NIP45

21 January 2018

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NIP45 controls the magnitude of the type 2 T helper cell response.

21 January 2018

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NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

21 January 2018

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NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells.

21 January 2018

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Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809703

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809703

Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809703

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809703

IL-4 directs the development of Th2-like helper effectors

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809703

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

16 September 2018

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12 December 2020

Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster

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12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

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12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

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12 December 2020

The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response

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12 December 2020

A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells

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12 December 2020

Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

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12 December 2020

GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet

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12 December 2020

Regulation of the Th2 cytokine locus by a locus control region

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12 December 2020

Stat5 activation plays a critical role in Th2 differentiation

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12 December 2020

Up-regulation of Hlx in immature Th cells induces IFN-gamma expression

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12 December 2020

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

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12 December 2020

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

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12 December 2020

GATA-3-dependent enhancer activity in IL-4 gene regulation

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12 December 2020

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

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12 December 2020

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

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12 December 2020

Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region

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12 December 2020

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

1 reference

12 December 2020

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

12 December 2020

Temporal and spatial changes of histone 3 K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation

1 reference

12 December 2020

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

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12 December 2020

Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection

1 reference

12 December 2020

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

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12 December 2020

Identifiers

DOI

10.1111/IMM.12121

1 reference

release_c6dk5d6g45gmpkqvjarruw5dom

28 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/c6dk5d6g45gmpkqvjarruw5dom

24 November 2022

mapped directly with Wikidata item

0 references

1 reference

PubMed ID

23668241