The acetylase activity of p300 is dispensable for MDM2 stabilization (Q40682154)

22 September 2017

The acetylase activity of p300 is dispensable for MDM2 stabilization (English)

1 reference

22 September 2017

Shelya X Zeng

1

1 reference

22 September 2017

Yetao Jin

2

1 reference

22 September 2017

David T Kuninger

3

1 reference

22 September 2017

Peter Rotwein

4

1 reference

22 September 2017

Hua Lu

5

1 reference

22 September 2017

language of work or name

English

0 references

publication date

18 December 2002

1 reference

Journal of Biological Chemistry

22 September 2017

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

22 September 2017

278

1 reference

22 September 2017

9

1 reference

22 September 2017

7453-7458

1 reference

The p300/CBP family: integrating signals with transcription factors and chromatin

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

p300 does not require its acetylase activity to stimulate p73 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Phosphorylated CREB binds specifically to the nuclear protein CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Histone deacetylases specifically down-regulate p53-dependent gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Deacetylation of p53 modulates its effect on cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Dual role of p300 in the regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Activation of p53 by oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Regulation of p63 function by Mdm2 and MdmX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Duration of nuclear NF-kappaB action regulated by reversible acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209030200

21 January 2018

Identifiers

DOI

10.1074/JBC.M209030200

1 reference

22 September 2017

1 reference