Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. (Q40649004)

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3 November 2019

title

Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R (English)

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3 November 2019

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4

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3 November 2019

author name string

Mikhail Roshal

1

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3 November 2019

Baek Kim

2

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3 November 2019

Yonghong Zhu

3

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3 November 2019

Vicente Planelles

5

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3 November 2019

language of work or name

English

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publication date

8 May 2003

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Journal of Biological Chemistry

3 November 2019

published in

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3 November 2019

volume

278

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3 November 2019

issue

28

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3 November 2019

page(s)

25879-25886

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The DNA damage response: putting checkpoints in perspective

3 November 2019

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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ATR Regulates Fragile Site Stability

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

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Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis

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Identification of a G(2) arrest domain in the E1 wedge E4 protein of human papillomavirus type 16.

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HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo

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Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes.

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Human immunodeficiency virus type 1 vpr protein transactivation function: mechanism and identification of domains involved

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Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1.

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Multigene lentiviral vectors based on differential splicing and translational control

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HTLV type 1 Tax transduction in microglial cells and astrocytes by lentiviral vectors

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

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HIV-1 Vpr transactivates LTR-directed expression through sequences present within -278 to -176 and increases virus replication in vitro.

21 January 2018

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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An extensive class of small RNAs in Caenorhabditis elegans

21 January 2018

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

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Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint

21 January 2018

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Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing

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Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

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Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr

21 January 2018

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HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303948200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12738771%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference