Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction. (Q40632785)

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19 December 2019

title

Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction (English)

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19 December 2019

1

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19 December 2019

author name string

Eder M

2

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19 December 2019

von Depka M

3

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19 December 2019

Battmer K

4

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19 December 2019

Luther S

5

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19 December 2019

Kiem HP

6

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19 December 2019

Ganser A

7

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19 December 2019

Scherr M

8

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19 December 2019

publication date

1 October 2003

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19 December 2019

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19 December 2019

volume

10

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19 December 2019

issue

22

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19 December 2019

page(s)

1917-1925

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302093

19 December 2019

exact match

0 references

cites work

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Short-term correction of factor VIII deficiency in a murine model of hemophilia A after delivery of adenovirus murine factor VIII in utero

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Partial correction of murine hemophilia A with neo-antigenic murine factor VIII.

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Adenovirus-mediated factor VIII gene expression results in attenuated anti-factor VIII-specific immunity in hemophilia A mice compared with factor VIII protein infusion

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Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs.

21 January 2018

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Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

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Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein

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Induction of tolerance to human factor VIII in mice

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Expression of human factor VIII by splicing between dimerized AAV vectors

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Evaluation of the duration of human factor VIII expression in nonhuman primates after systemic delivery of an adenoviral vector

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Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice

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In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors.

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Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo

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Toward gene therapy for hemophilia A: long-term persistence of factor VIII-secreting fibroblasts after transplantation into immunodeficient mice.

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Nonviral transfer of the gene encoding coagulation factor VIII in patients with severe hemophilia A.

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Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice

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HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells

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The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain.

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Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo

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Tolerance, danger, and the extended family

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Identifiers

DOI

10.1038/SJ.GT.3302093

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502221%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 December 2019

0 references

1 reference