Line-walking method for predicting the inhibition of P450 drug metabolism (Q40604764)

22 September 2017

Line-walking method for predicting the inhibition of P450 drug metabolism (English)

1 reference

22 September 2017

Matthew G Hudelson

1

1 reference

22 September 2017

Jeffrey P Jones

series ordinal

2

1 reference

22 September 2017

language of work or name

English

0 references

publication date

1 July 2006

1 reference

Journal of Medicinal Chemistry

22 September 2017

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22 September 2017

49

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22 September 2017

14

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22 September 2017

4367-4373

1 reference

Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

A rapid computational filter for cytochrome P450 1A2 inhibition potential of compound libraries

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Quantitative binding models for CYP2C9 based on benzbromarone analogues

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Comparison of linear and nonlinear classification algorithms for the prediction of drug and chemical metabolism by human UDP-glucuronosyltransferase isoforms

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Use of robust classification techniques for the prediction of human cytochrome P450 2D6 inhibition

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Atypical kinetic profiles in drug metabolism reactions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Comparison of the predicted and observed secondary structure of T4 phage lysozyme

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Predicting the cytochrome P450 mediated metabolism of xenobiotics.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

The inhibition of human prostatic aromatase activity by imidazole drugs including ketoconazole and 4-hydroxyandrostenedione.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Prediction of cytochrome P450 3A4, 2D6, and 2C9 inhibitors and substrates by using support vector machines.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Development of CYP3A4 inhibition models: comparisons of machine-learning techniques and molecular descriptors.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Greater than the sum of its parts: combining models for useful ADMET prediction

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

Generation and validation of rapid computational filters for cyp2d6 and cyp3a4.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

QSAR model for drug human oral bioavailability.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871544

A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions

20 August 2018

1 reference

12 December 2020

Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction

1 reference

12 December 2020

Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9

1 reference

12 December 2020

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

12 December 2020

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding

1 reference

12 December 2020

Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM0601553

1 reference

release_zfu4xiszwzc5raldptny4sfm4m

22 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zfu4xiszwzc5raldptny4sfm4m

24 November 2022

mapped directly with Wikidata item

1 reference

22 September 2017

1 reference