Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases (Q40569645)

21 September 2017

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title

Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases (English)

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21 September 2017

J C Hutton

1

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21 September 2017

1 September 1994

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21 September 2017

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21 September 2017

37 Suppl 2

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21 September 2017

S48-56

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https://scigraph.springernature.com/pub.10.1007/bf00400826

21 September 2017

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cites work

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

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12 December 2020

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

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12 December 2020

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

1 reference

12 December 2020

Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.

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12 December 2020

Induction of specific storage organelles by von Willebrand factor propolypeptide

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12 December 2020

Constitutive and regulated secretion of proteins

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12 December 2020

A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase

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12 December 2020

Membranes of the adrenal medulla. Behaviour of insoluble proteins of chromaffin granules on gel electrophoresis

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12 December 2020

Secretory carrier membrane proteins 31-35 define a common protein composition among secretory carrier membranes

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12 December 2020

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

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12 December 2020

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes

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12 December 2020

Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes

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12 December 2020

Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family

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12 December 2020

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.

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12 December 2020

Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases

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12 December 2020

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

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12 December 2020

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles

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12 December 2020

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

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12 December 2020

Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene

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12 December 2020

Efficient targeting to storage granules of human proinsulins with altered propeptide domain

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12 December 2020

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells

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12 December 2020

The new enzymology of precursor processing endoproteases

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12 December 2020

The trans Golgi network: sorting at the exit site of the Golgi complex.

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12 December 2020

Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules

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12 December 2020

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

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12 December 2020

An antibody against secretogranin I (chromogranin B) is packaged into secretory granules

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12 December 2020

Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10).

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12 December 2020

Pathways to regulated exocytosis in neurons

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12 December 2020

A major C-peptide deletion prevents secretion of a mutant human proinsulin from transfected monkey kidney cells

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12 December 2020

Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans

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12 December 2020

Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells

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12 December 2020

Direct identification of prohormone conversion site in insulin-secreting cells

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12 December 2020

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets

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12 December 2020

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites

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12 December 2020

Production and characterization of monoclonal antibodies to insulin secretory granule membranes

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12 December 2020

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

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12 December 2020

Identification of kex2-related proteases in chromaffin granules by partial amino acid sequence analysis

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12 December 2020

The internal pH and membrane potential of the insulin-secretory granule

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12 December 2020

Sequence requirements for processing of proinsulin in transfected mouse pituitary AtT20 cells

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12 December 2020

Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins

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12 December 2020

ATP-driven H+ pumping into intracellular organelles

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12 December 2020

The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides

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12 December 2020

The recycling of a secretory granule membrane protein

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12 December 2020

Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

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12 December 2020

Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes

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12 December 2020

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12 December 2020

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

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12 December 2020

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

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12 December 2020

Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 pituitary cells

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12 December 2020

Protein sorting and secretion granule formation in regulated secretory cells

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12 December 2020

Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents

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12 December 2020

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

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12 December 2020

Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.

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12 December 2020

Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

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12 December 2020

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans

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12 December 2020

The insulin secretory granule

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12 December 2020

Pancreatic B-cells secrete a range of novel peptides besides insulin

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12 December 2020

Molecular sorting in the secretory pathway

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12 December 2020

(Pro)insulin associates with Golgi membranes of pancreatic B cells

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12 December 2020

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site

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12 December 2020

Identifiers

DOI

10.1007/BF00400826

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21 September 2017

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PubMed ID

7821740