mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. (Q40537683)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27637146%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation (English)

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23 March 2020

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13

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23 March 2020

Hu Zeng

1

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23 March 2020

Ben Youngblood

10

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23 March 2020

Hongbo Chi

15

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23 March 2020

author name string

Sivan Cohen

2

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23 March 2020

Cliff Guy

3

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23 March 2020

Sharad Shrestha

4

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23 March 2020

Geoffrey Neale

5

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23 March 2020

Scott A Brown

6

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23 March 2020

Caryn Cloer

7

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23 March 2020

Rigel J Kishton

8

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23 March 2020

Xia Gao

9

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23 March 2020

Mytrang Do

11

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23 March 2020

Ming O Li

12

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23 March 2020

Jeffrey C Rathmell

14

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23 March 2020

language of work or name

English

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publication date

13 September 2016

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23 March 2020

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23 March 2020

volume

45

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23 March 2020

issue

3

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23 March 2020

page(s)

540-554

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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

23 March 2020

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1 reference

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PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development

17 June 2018

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LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

17 June 2018

1 reference

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mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation

17 June 2018

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ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

17 June 2018

1 reference

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ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.

17 June 2018

1 reference

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Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

17 June 2018

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T follicular helper cell differentiation, function, and roles in disease

17 June 2018

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Bcl-6 directly represses the gene program of the glycolysis pathway

17 June 2018

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The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

17 June 2018

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The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells

17 June 2018

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Development and quantitative evaluation of a high-resolution metabolomics technology

17 June 2018

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T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

17 June 2018

1 reference

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mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

17 June 2018

1 reference

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MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation

17 June 2018

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Metabolic regulation of T lymphocytes

17 June 2018

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

17 June 2018

1 reference

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Novel Foxo1-dependent transcriptional programs control T(reg) cell function

17 June 2018

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FOXO transcription factors throughout T cell biology

17 June 2018

1 reference

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Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

17 June 2018

1 reference

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Regulation and function of mTOR signalling in T cell fate decisions

17 June 2018

1 reference

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Early Th1 cell differentiation is marked by a Tfh cell-like transition

17 June 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

17 June 2018

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Foxp3+ follicular regulatory T cells control the germinal center response.

17 June 2018

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Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

17 June 2018

1 reference

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

17 June 2018

1 reference

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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

17 June 2018

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17 June 2018

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Foxo transcription factors control regulatory T cell development and function

17 June 2018

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Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

17 June 2018

1 reference

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Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

17 June 2018

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Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis

17 June 2018

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Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

17 June 2018

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PI3 kinase signals BCR-dependent mature B cell survival

17 June 2018

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Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

17 June 2018

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An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance

17 June 2018

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

17 June 2018

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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

17 June 2018

1 reference

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Essential role for nuclear PTEN in maintaining chromosomal integrity

17 June 2018

1 reference

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T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

17 June 2018

1 reference

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The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.

17 June 2018

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Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.

20 August 2018

1 reference

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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

20 August 2018

1 reference

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Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli.

20 August 2018

1 reference

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The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches

20 August 2018

1 reference

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10.1016/J.IMMUNI.2016.08.017

20 August 2018

Identifiers

DOI

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23 March 2020

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23 March 2020

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