Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. (Q40494567)

21 September 2017

Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. (English)

1 reference

21 September 2017

0 references

Eun Hee Kim

1

1 reference

21 September 2017

Seung U Kim

series ordinal

2

1 reference

21 September 2017

Kyeong Sook Choi

series ordinal

3

1 reference

21 September 2017

language of work or name

English

0 references

publication date

1 January 2005

1 reference

21 September 2017

1 reference

21 September 2017

24

1 reference

21 September 2017

5

1 reference

21 September 2017

838-849

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208241

21 September 2017

0 references

cites work

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Validating survivin as a cancer therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Safety and antitumor activity of recombinant soluble Apo2 ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Involvement of protein kinase C-delta in DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

IAP family proteins--suppressors of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Rottlerin, a novel protein kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Neuroimmunology of gangliosides in human neurons and glial cells in culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: role of XIAP in resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

A p34(cdc2) survival checkpoint in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

APO2 ligand: a novel lethal weapon against malignant glioma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Identification and characterization of a new member of the TNF family that induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

Quantitatively determined survivin expression levels are of prognostic value in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

Protein kinase C isozymes and the regulation of diverse cell responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

E2F target genes and cell-cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208241

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208241

1 reference

Dimensions Publication ID

21 September 2017

0 references

1 reference