Reversing deleterious protein aggregation with re-engineered protein disaggregases. (Q40464905)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Reversing deleterious protein aggregation with re-engineered protein disaggregases (English)

1 reference

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12 March 2020

1 reference

1

1 reference

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12 March 2020

James Shorter

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Meredith E Jackrel

series ordinal

1

1 reference

20 September 2017

James Shorter

series ordinal

2

1 reference

20 September 2017

language of work or name

1 reference

2 April 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

13

1 reference

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12 March 2020

issue

9

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12 March 2020

page(s)

1379-1383

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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

12 March 2020

cites work

1 reference

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Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

22 September 2017

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Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110

22 September 2017

1 reference

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Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.

22 September 2017

1 reference

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Chaperone machines for protein folding, unfolding and disaggregation

22 September 2017

1 reference

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Distinct α-synuclein strains differentially promote tau inclusions in neurons

22 September 2017

1 reference

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Molecular chaperone functions in protein folding and proteostasis

22 September 2017

1 reference

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Hsp110 is a bona fide chaperone using ATP to unfold stable misfolded polypeptides and reciprocally collaborate with Hsp70 to solubilize protein aggregates.

22 September 2017

1 reference

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The changing scene of amyotrophic lateral sclerosis

22 September 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

22 September 2017

1 reference

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Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

22 September 2017

1 reference

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Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

22 September 2017

1 reference

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

22 September 2017

1 reference

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The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

22 September 2017

1 reference

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The elusive middle domain of Hsp104 and ClpB: location and function.

22 September 2017

1 reference

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A yeast model of FUS/TLS-dependent cytotoxicity

22 September 2017

1 reference

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Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

22 September 2017

1 reference

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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

22 September 2017

1 reference

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Prion-like disorders: blurring the divide between transmissibility and infectivity

22 September 2017

1 reference

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Applying Hsp104 to protein-misfolding disorders.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

22 September 2017

1 reference

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

22 September 2017

1 reference

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Prion proteostasis: Hsp104 meets its supporting cast

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Hsp104: a weapon to combat diverse neurodegenerative disorders.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

22 September 2017

1 reference

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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Protein folding and misfolding

22 September 2017

1 reference

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

22 September 2017

1 reference

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Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

25 September 2017

1 reference

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The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Yeast cells provide insight into alpha-synuclein biology and pathobiology

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050135

Stress, aging, and neurodegenerative disease

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24694655

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24694655

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CC.28709

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694655%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference