Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain (Q40436447)

20 September 2017

Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain (English)

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20 September 2017

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Martijn P Lolkema

1

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20 September 2017

Michelle L Gervais

2

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20 September 2017

Cristel M Snijckers

3

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20 September 2017

Richard P Hill

4

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20 September 2017

Rachel H Giles

5

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20 September 2017

Emile E Voest

6

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20 September 2017

Michael Ohh

7

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20 September 2017

language of work or name

English

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publication date

11 April 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

22205-22211

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20 September 2017

23

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von Hippel-Lindau disease

20 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

A polymeric form of fibronectin has antimetastatic effects against multiple tumor types.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M503220200

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Fibronectin is a hypoxia-independent target of the tumor suppressor VHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

One-thousand-and-one substrates of protein kinase CK2?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Changes in gene expression during chemical‐induced nephrocarcinogenicity in the Eker rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Direct regulation of microtubule dynamics by protein kinase CK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Distribution of CK2, its substrate MAP1B and phosphatases in neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503220200

21 January 2018

Identifiers

DOI

10.1074/JBC.M503220200

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20 September 2017

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