RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. (Q40375910)

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6 January 2020

title

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo (English)

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8

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author name string

Laurent Désiré

1

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6 January 2020

Jérôme Bourdin

2

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6 January 2020

Nadia Loiseau

3

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Hélène Peillon

4

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6 January 2020

Virginie Picard

5

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6 January 2020

Catherine De Oliveira

6

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Florence Bachelot

7

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6 January 2020

Thierry Taverne

9

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Eric Beausoleil

10

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6 January 2020

Sandrine Lacombe

11

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Dominique Drouin

12

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Fabien Schweighoffer

13

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language of work or name

English

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publication date

8 September 2005

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Journal of Biological Chemistry

6 January 2020

number of pages

10

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based on heuristic

inferred from page(s)

published in

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6 January 2020

volume

280

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6 January 2020

page(s)

37516-37525

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6 January 2020

issue

45

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Alzheimer's disease: the amyloid cascade hypothesis

6 January 2020

cites work

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A fluid connection: cholesterol and Abeta

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A detergent-insoluble membrane compartment contains A beta in vivo.

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

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Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

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Biochemical and morphological analysis on the localization of Rac1 in neurons

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Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

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Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

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Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage.

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

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PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

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Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

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BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M507913200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16150730%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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