Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase (Q40368140)

19 September 2017

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase (English)

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19 September 2017

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4

Martin Marquis

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19 September 2017

1

George Kukolj

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19 September 2017

3

Ginette McKercher

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19 September 2017

9

Marc-André Poupart

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19 September 2017

Graham A McGibbon

2

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19 September 2017

Sylvain Lefèbvre

5

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19 September 2017

Louise Thauvette

6

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19 September 2017

Jean Gauthier

7

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19 September 2017

Sylvie Goulet

8

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19 September 2017

Pierre L Beaulieu

10

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19 September 2017

language of work or name

English

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publication date

27 September 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

280

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19 September 2017

39260-39267

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19 September 2017

47

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

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21 January 2018

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

21 January 2018

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

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A mechanism for initiating RNA-dependent RNA polymerization

21 January 2018

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A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

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Bacteriophage phi 6 RNA-dependent RNA polymerase: molecular details of initiating nucleic acid synthesis without primer

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Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer

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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

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Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.

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The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy

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Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft

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Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase

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Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

21 January 2018

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HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis

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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

21 January 2018

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

21 January 2018

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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives

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Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells

21 January 2018

1 reference

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency

21 January 2018

1 reference

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Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy

21 January 2018

1 reference

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Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

21 January 2018

1 reference

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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate

21 January 2018

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Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

21 January 2018

1 reference

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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

21 January 2018

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Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans

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Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry

21 January 2018

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An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.

21 January 2018

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RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region

21 January 2018

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

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Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis

21 January 2018

1 reference

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

21 January 2018

1 reference

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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

21 January 2018

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms

21 January 2018

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

21 January 2018

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Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro

21 January 2018

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

21 January 2018

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Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

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Crystallization and preliminary X-ray crystallographic studies on the bacteriophage Φ6 RNA-dependent RNA polymerase

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21 January 2018

Identifiers

DOI

10.1074/JBC.M506407200

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19 September 2017

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