alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity (Q40327562)

19 September 2017

alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity (English)

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19 September 2017

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Katrina A Brandis

1

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19 September 2017

Isaac F Holmes

2

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19 September 2017

Samantha J England

3

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19 September 2017

Nijee Sharma

4

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19 September 2017

Lokesh Kukreja

5

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19 September 2017

Shubhik K DebBurman

6

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19 September 2017

1 January 2006

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Journal of Molecular Neuroscience

19 September 2017

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19 September 2017

28

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19 September 2017

2

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19 September 2017

179-191

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https://scigraph.springernature.com/pub.10.1385/jmn:28:2:179

19 September 2017

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12 December 2020

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Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

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Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

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Yeast cells provide insight into alpha-synuclein biology and pathobiology

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Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

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Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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12 December 2020

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

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12 December 2020

The genome sequence of Schizosaccharomyces pombe

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12 December 2020

Toxic proteins in neurodegenerative disease

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12 December 2020

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions.

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12 December 2020

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

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12 December 2020

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

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12 December 2020

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

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12 December 2020

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

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12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

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12 December 2020

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

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12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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12 December 2020

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe

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12 December 2020

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

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12 December 2020

Metabolism of the phospholipid precursor inositol and its relationship to growth and viability in the natural auxotroph Schizosaccharomyces pombe

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12 December 2020

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12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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12 December 2020

Identifiers

DOI

10.1385/JMN:28:2:179

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Dimensions Publication ID

19 September 2017

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