Molecular genetics approaches in yeast to study amyloid diseases (Q35764314)

10 August 2017

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title

Molecular genetics approaches in yeast to study amyloid diseases (English)

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10 August 2017

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Tiago Fleming Outeiro

series ordinal

1

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PubMed ID

15126692

10 August 2017

Paul J Muchowski

series ordinal

2

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10 August 2017

1 January 2004

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Journal of Molecular Neuroscience

10 August 2017

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10 August 2017

23

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10 August 2017

1-2

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10 August 2017

49-60

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https://scigraph.springernature.com/pub.10.1385/jmn:23:1-2:049

10 August 2017

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cites work

The yeast connection to Friedreich ataxia.

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12 December 2020

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

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12 December 2020

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

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12 December 2020

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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12 December 2020

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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12 December 2020

Genetic suppression of polyglutamine toxicity in Drosophila

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12 December 2020

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

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12 December 2020

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12 December 2020

Getting started with yeast

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.

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12 December 2020

Aggresomes: a cellular response to misfolded proteins

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12 December 2020

Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria.

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12 December 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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12 December 2020

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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12 December 2020

Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase

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12 December 2020

Glutamine repeats and neurodegeneration

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12 December 2020

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

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12 December 2020

Prions as protein-based genetic elements

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12 December 2020

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

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12 December 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Aggresomes, inclusion bodies and protein aggregation

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12 December 2020

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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12 December 2020

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

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12 December 2020

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

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12 December 2020

From Charcot to SOD1: mechanisms of selective motor neuron death in ALS.

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12 December 2020

Expanded polyglutamine stretches form an 'aggresome'.

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12 December 2020

A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity

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12 December 2020

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Superoxide radical and superoxide dismutases

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12 December 2020

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

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12 December 2020

A biochemical genomics approach for identifying genes by the activity of their products.

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12 December 2020

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

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12 December 2020

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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12 December 2020

Identification of genes that modify ataxin-1-induced neurodegeneration.

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Huntington's disease: the challenge for cell biologists

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12 December 2020

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.

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12 December 2020

Functional profiling of the Saccharomyces cerevisiae genome

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12 December 2020

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

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12 December 2020

Amyloid fibrillogenesis: themes and variations

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12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

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12 December 2020

Investigating protein conformation-based inheritance and disease in yeast

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12 December 2020

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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12 December 2020

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

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12 December 2020

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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12 December 2020

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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12 December 2020

Systematic screen for human disease genes in yeast

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12 December 2020

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

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12 December 2020

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Recent advances in the molecular pathogenesis of Friedreich ataxia

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12 December 2020

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

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12 December 2020

Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

1 reference

12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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12 December 2020

Neuropathology in mice expressing human alpha-synuclein

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12 December 2020

Alpha-synuclein and neurodegenerative diseases

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12 December 2020

Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.

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12 December 2020

Large-scale analysis of the yeast genome by transposon tagging and gene disruption

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12 December 2020

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

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12 December 2020

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

1 reference

12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

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12 December 2020

Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

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12 December 2020

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

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12 December 2020

alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

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12 December 2020

A network of protein-protein interactions in yeast

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12 December 2020

Synucleins in synaptic plasticity and neurodegenerative disorders

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12 December 2020

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

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12 December 2020

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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12 December 2020

Identifiers

DOI

10.1385/JMN:23:1-2:049

1 reference

PubMed ID

15126692

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15126692