TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling (Q40320864)

19 September 2017

TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling (English)

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19 September 2017

Stacie M Kutz

1

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19 September 2017

Craig E Higgins

2

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19 September 2017

Rohan Samarakoon

3

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19 September 2017

Stephen P Higgins

4

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19 September 2017

Rosalie R Allen

5

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19 September 2017

Li Qi

6

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19 September 2017

Paul J Higgins

7

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19 September 2017

language of work or name

English

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publication date

7 February 2006

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Experimental Cell Research

19 September 2017

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19 September 2017

312

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19 September 2017

1093-1105

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19 September 2017

7

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Antisense targeting of c-fos transcripts inhibits serum- and TGF-beta 1-stimulated PAI-1 gene expression and directed motility in renal epithelial cells

19 September 2017

1 reference

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Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

7 January 2021

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Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation

7 January 2021

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Regulation of cell proliferation by Smad proteins

7 January 2021

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

7 January 2021

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

7 January 2021

1 reference

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Growth state-dependent regulation of plasminogen activator inhibitor type-1 gene expression during epithelial cell stimulation by serum and transforming growth factor-beta1.

7 January 2021

1 reference

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Targets of transcriptional regulation by transforming growth factor-beta: expression profile analysis using oligonucleotide arrays

7 January 2021

1 reference

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High-throughput mapping of a dynamic signaling network in mammalian cells

7 January 2021

1 reference

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

7 January 2021

1 reference

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Linking epithelial-mesenchymal transition to the well-known polarity protein Par6

7 January 2021

1 reference

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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

7 January 2021

1 reference

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Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro

7 January 2021

1 reference

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Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations.

7 January 2021

1 reference

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Epithelial monolayer wounding stimulates binding of USF-1 to an E-box motif in the plasminogen activator inhibitor type 1 gene

7 January 2021

1 reference

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The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.

7 January 2021

1 reference

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PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair

7 January 2021

1 reference

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Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene

7 January 2021

1 reference

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Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

7 January 2021

1 reference

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

7 January 2021

1 reference

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Upstream stimulatory factor regulates E box-dependent PAI-1 transcription in human epidermal keratinocytes

7 January 2021

1 reference

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Growth state-dependent binding of USF-1 to a proximal promoter E box element in the rat plasminogen activator inhibitor type 1 gene

7 January 2021

1 reference

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Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1.

7 January 2021

1 reference

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The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.

7 January 2021

1 reference

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Induced PAI-1 mRNA expression and targeted protein accumulation are early G1 events in serum-stimulated rat kidney cells

7 January 2021

1 reference

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Attenuation of plasminogen activator inhibitor type-1 promoter activity in serum-stimulated renal epithelial cells by a distal 5' flanking region

7 January 2021

1 reference

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The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site

7 January 2021

1 reference

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Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent

7 January 2021

1 reference

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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

7 January 2021

1 reference

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Transforming growth factor-beta signal transduction in epithelial cells.

7 January 2021

1 reference

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TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling.

7 January 2021

1 reference

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Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

7 January 2021

1 reference

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Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor

7 January 2021

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The EGF receptor as central transducer of heterologous signalling systems

7 January 2021

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Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells

7 January 2021

1 reference

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Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

7 January 2021

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STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor

7 January 2021

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Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1.

7 January 2021

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Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion

7 January 2021

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Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells

7 January 2021

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c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.

7 January 2021

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Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells

7 January 2021

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Urokinase-induced smooth muscle cell responses require distinct signaling pathways: a role for the epidermal growth factor receptor

7 January 2021

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EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases

7 January 2021

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Involvement of HB-EGF and EGF receptor transactivation in TGF-beta-mediated fibronectin expression in mesangial cells

7 January 2021

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c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

7 January 2021

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Src family tyrosine kinases and growth factor signaling

7 January 2021

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Sensing the environment: a historical perspective on integrin signal transduction

7 January 2021

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Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells

7 January 2021

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Submicromolar doses of alkyl-lysophospholipids induce rapid internalization, but not activation, of epidermal growth factor receptor and concomitant MAPK/ERK activation in A431 cells

7 January 2021

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Role of Raf in vascular protection from distinct apoptotic stimuli

7 January 2021

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

7 January 2021

1 reference

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CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

7 January 2021

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ERK activation upon hypoxia: involvement in HIF-1 activation

7 January 2021

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Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease

7 January 2021

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Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy

7 January 2021

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Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes

7 January 2021

1 reference

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Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.

7 January 2021

1 reference

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Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.

7 January 2021

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Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells

7 January 2021

1 reference

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Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration

7 January 2021

1 reference

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Physical and Functional Interactions between USF and Sp1 Proteins Regulate Human Deoxycytidine Kinase Promoter Activity

7 January 2021

1 reference

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Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

7 January 2021

1 reference

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7 January 2021

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Identifiers

DOI

10.1016/J.YEXCR.2005.12.027

1 reference

19 September 2017

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