CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation (Q34413075)

2 August 2017

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation (English)

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2 August 2017

Algirdas Ziogas

1

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2 August 2017

Karin Moelling

series ordinal

2

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2 August 2017

Gerald Radziwill

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

21 April 2005

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Journal of Biological Chemistry

2 August 2017

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2 August 2017

280

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2 August 2017

25

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2 August 2017

24205-24211

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Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins

2 August 2017

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Conferring specificity on the ubiquitous Raf/MEK signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The RAF proteins take centre stage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Docking domains and substrate-specificity determination for MAP kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

The complexity of Raf-1 regulation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Untying the regulation of the Raf-1 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Phosphorylation of c-Raf-1 by protein kinase A interferes with activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Mutations of the BRAF gene in human cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

KSR modulates signal propagation within the MAPK cascade

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

CNK, a RAF-binding multidomain protein required for RAS signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Bimodal regulation of RAF by CNK in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Functional analysis of CNK in RAS signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

Critical contribution of linker proteins to Raf kinase activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M413327200

CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The JIP group of mitogen-activated protein kinase scaffold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Signal transduction: hanging on a scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

An old kinase on a new path: Raf and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Cortactin: coupling membrane dynamics to cortical actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413327200

21 January 2018

Identifiers

DOI

10.1074/JBC.M413327200

1 reference

2 August 2017

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