TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease (Q40311429)

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scientific article published on 18 November 2015

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English	TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease	scientific article published on 18 November 2015

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scholarly article

1 reference

Europe PubMed Central

19 September 2017

TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease (English)

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Europe PubMed Central

19 September 2017

Alzheimer's disease

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1 reference

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author name string

Lei Gao

1

1 reference

Europe PubMed Central

19 September 2017

Mi Tian

2

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Europe PubMed Central

19 September 2017

Hong-Yun Zhao

3

1 reference

Europe PubMed Central

19 September 2017

Qian-Qian Xu

4

1 reference

Europe PubMed Central

19 September 2017

Yu-Ming Huang

5

1 reference

Europe PubMed Central

19 September 2017

Qun-Cao Si

6

1 reference

Europe PubMed Central

19 September 2017

Qing Tian

7

1 reference

Europe PubMed Central

19 September 2017

Qing-Ming Wu

8

1 reference

Europe PubMed Central

19 September 2017

Xia-Min Hu

9

1 reference

Europe PubMed Central

19 September 2017

Li-Bo Sun

10

1 reference

Europe PubMed Central

19 September 2017

Shawn M McClintock

11

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Europe PubMed Central

19 September 2017

Yan Zeng

12

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Europe PubMed Central

19 September 2017

language of work or name

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publication date

18 November 2015

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Europe PubMed Central

19 September 2017

Journal of Neurochemistry

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Europe PubMed Central

19 September 2017

136

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Europe PubMed Central

19 September 2017

620-636

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Europe PubMed Central

19 September 2017

3

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Europe PubMed Central

19 September 2017

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

The neuronal activity-driven transcriptome.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor is reduced in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Activity- and BDNF-induced plasticity of miniature synaptic currents in ES cell-derived neurons integrated in a neocortical network

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Hippocampal mossy fiber distribution covaries with open-field habituation in the mouse.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

A function-structure model for NGF-activated TRK

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor-dependent unmasking of "silent" synapses in the developing mouse barrel cortex

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Cleavage of proBDNF to BDNF by a tolloid-like metalloproteinase is required for acquisition of in vitro eyeblink classical conditioning

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Coordinate action of pre- and postsynaptic brain-derived neurotrophic factor is required for AMPAR trafficking and acquisition of in vitro classical conditioning

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Pathways towards and away from Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

CREB is necessary for synaptic maintenance and learning-induced changes of the AMPA receptor GluA1 subunit

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor regulates the expression of AMPA receptor proteins in neocortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

New insights into brain BDNF function in normal aging and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Amyloid beta from axons and dendrites reduces local spine number and plasticity.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Submicromolar Aβ42 reduces hippocampal glutamate receptors and presynaptic markers in an aggregation-dependent manner

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Small molecules activating TrkB receptor for treating a variety of CNS disorders

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

No significant effect of 7,8-dihydroxyflavone on APP processing and Alzheimer-associated phenotypes.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Brain-derived neurotrophic factor in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13432

21 January 2018

Identifiers

10.1111/JNC.13432

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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