Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex (Q40304293)

19 September 2017

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex (English)

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19 September 2017

Frank Peelman

1

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19 September 2017

Hannes Iserentant

2

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19 September 2017

Anne-Sophie De Smet

3

1 reference

19 September 2017

Joël Vandekerckhove

4

1 reference

19 September 2017

Lennart Zabeau

5

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19 September 2017

Jan Tavernier

6

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19 September 2017

language of work or name

English

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publication date

15 March 2006

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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19 September 2017

22

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19 September 2017

15496-15504

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Positional cloning of the mouse obese gene and its human homologue

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The weight of leptin in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Crystal structure of the obese protein leptin-E100

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Threading analysis suggests that the obese gene product may be a helical cytokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The ins and outs of leptin receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Mapping of the leptin binding sites and design of a leptin antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Receptor recognition by gp130 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

A highly sensitive selection method for directed evolution of homing endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

T-Coffee: A novel method for fast and accurate multiple sequence alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Mapping of the interface between leptin and the leptin receptor CRH2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The FSSP database: fold classification based on structure-structure alignment of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The Pfam protein families database

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Human and mouse oligonucleotide-based array CGH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Structure of an extracellular gp130 cytokine receptor signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Signal transduction through the receptor for erythropoietin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Expression, purification, and characterization of the active immunoglobulin-like domain of human granulocyte-colony-stimulating factor receptor in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512622200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512622200

1 reference

19 September 2017

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