Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells (Q40293334)

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scientific article published on 21 November 2015

Language	Label	Description	Also known as
English	Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells	scientific article published on 21 November 2015

Statements

scholarly article

1 reference

Europe PubMed Central

19 September 2017

Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells (English)

1 reference

Europe PubMed Central

19 September 2017

author name string

Tomohiro Hirade

1

1 reference

Europe PubMed Central

19 September 2017

Mariko Abe

2

1 reference

Europe PubMed Central

19 September 2017

Chie Onishi

3

1 reference

Europe PubMed Central

19 September 2017

Takeshi Taketani

4

1 reference

Europe PubMed Central

19 September 2017

Seiji Yamaguchi

5

1 reference

Europe PubMed Central

19 September 2017

Seiji Fukuda

6

1 reference

Europe PubMed Central

19 September 2017

publication date

21 November 2015

1 reference

Europe PubMed Central

19 September 2017

International Journal of Hematology

1 reference

Europe PubMed Central

19 September 2017

103

1 reference

Europe PubMed Central

19 September 2017

1

1 reference

Europe PubMed Central

19 September 2017

95-106

1 reference

Europe PubMed Central

19 September 2017

https://scigraph.springernature.com/pub.10.1007/s12185-015-1908-8

0 references

The role of FLT3 in haematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

The roles of FLT3 in hematopoiesis and leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Drug resistance in mutant FLT3-positive AML.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Secondary mutations as mediators of resistance to targeted therapy in leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Core-binding factors in haematopoiesis and leukaemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Runx regulation of sphingolipid metabolism and survival signaling.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Runx1 promotes B-cell survival and lymphoma development

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Integration of biological networks and gene expression data using Cytoscape

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Molecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells: implications for the biological properties of AML blasts.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

The Runx genes: lineage-specific oncogenes and tumor suppressors

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Gene mutations of acute myeloid leukemia in the genome era.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

New mechanisms of AML1 gene alteration in hematological malignancies

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

AML1 gene over-expression in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

The RUNX genes: gain or loss of function in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

A role for RUNX1 in hematopoiesis and myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Runx1 loss minimally impacts long-term hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

1 reference

https://api.crossref.org/works/10.1007%2FS12185-015-1908-8

21 January 2018

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 INHIBITORS: RECENT ADVANCES AND PROBLEMS FOR CLINICAL APPLICATION.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - a cDNA array study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An acute myeloid leukemia gene, AML1, regulates transcriptional activation and hemopoietic myeloid cell differentiation antagonistically by two alternative spliced forms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/26590920

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12185-015-1908-8

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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