Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations (Q34011740)

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English	Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations	scientific article

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scholarly article

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Europe PubMed Central

30 July 2017

Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations (English)

1 reference

Europe PubMed Central

30 July 2017

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acute myeloid leukemia

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based on heuristic

inferred from title

Hagop Kantarjian

2

object named as

Hagop M Kantarjian

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Europe PubMed Central

30 July 2017

8

object named as

Zeev Estrov

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Europe PubMed Central

30 July 2017

4

object named as

Farhad Ravandi

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Europe PubMed Central

30 July 2017

Gautam Borthakur

5

object named as

Gautam Borthakur

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30 July 2017

Guillermo Garcia-Manero

6

object named as

Guillermo Garcia-Manero

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Europe PubMed Central

30 July 2017

Marina Konopleva

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object named as

Marina Konopleva

1 reference

Europe PubMed Central

30 July 2017

Michael Andreeff

9

object named as

Michael Andreeff

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Europe PubMed Central

30 July 2017

Jorge Eduardo Cortes

10

object named as

Jorge E Cortes

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30 July 2017

Rajyalakshmi Luthra

3

object named as

Rajyalakshmi Luthra

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Europe PubMed Central

30 July 2017

author name string

Yesid Alvarado

1

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30 July 2017

language of work or name

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publication date

15 April 2014

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30 July 2017

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Europe PubMed Central

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120

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30 July 2017

14

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Europe PubMed Central

30 July 2017

2142-2149

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Europe PubMed Central

30 July 2017

Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124083

5 July 2018

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

1 reference

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5 July 2018

FLT3/ITD AML and the law of unintended consequences

1 reference

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5 July 2018

FLT3 inhibitors in the treatment of acute myeloid leukemia: the start of an era?

1 reference

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5 July 2018

FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo

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5 July 2018

Phase I study of sorafenib in patients with refractory or relapsed acute leukemias

1 reference

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5 July 2018

Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.

1 reference

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FLT3 as a therapeutic target in AML: still challenging after all these years

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Cancer statistics, 2010

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Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells

1 reference

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5 July 2018

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation

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High-dose daunorubicin in older patients with acute myeloid leukemia

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5 July 2018

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

1 reference

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Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation

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5 July 2018

FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro

1 reference

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5 July 2018

A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.

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5 July 2018

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.

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5 July 2018

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

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5 July 2018

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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5 July 2018

Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

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5 July 2018

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

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5 July 2018

FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

1 reference

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5 July 2018

Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways

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5 July 2018

The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

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5 July 2018

Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

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5 July 2018

A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

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5 July 2018

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

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5 July 2018

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.

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5 July 2018

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

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Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD–transformed hematopoietic cells

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5 July 2018

The role of FLT3 in haematopoietic malignancies

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Detection of FLT3 Internal Tandem Duplication and D835 Mutations by a Multiplex Polymerase Chain Reaction and Capillary Electrophoresis Assay

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

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The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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5 July 2018

Evaluation of survival data and two new rank order statistics arising in its consideration

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Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

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FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype.

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Impact of FLT3 internal tandem duplication on the outcome of related and unrelated hematopoietic transplantation for adult acute myeloid leukemia in first remission: a retrospective analysis.

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Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis

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Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

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Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

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12 December 2020

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Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome

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12 December 2020

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Prognostic significance of FLT3 ITD and D835 mutations in AML patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24737502

12 December 2020

based on heuristic

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Prevalence and prognostic significance of FLT3 gene mutations in patients with acute leukaemia: analysis of patients from the Shanghai Leukaemia Co-operative Group

1 reference

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12 December 2020

based on heuristic

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Identifiers

10.1002/CNCR.28705

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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