Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics (Q40287573)

19 September 2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics (English)

1 reference

19 September 2017

Nicolas L Fawzi

23

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Denes Kovacs

Denes Kovacs

3

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Philip Van Damme

Philip Van Damme

25

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Joost Schymkowitz

Joost Schymkowitz

21

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Dirk Daelemans

Dirk Daelemans

15

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J Paul Taylor

J Paul Taylor

16

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Ludo Van Den Bosch

Ludo Van Den Bosch

27

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Frank Sobott

Frank Sobott

20

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Wim Robberecht

24

Wim Robberecht

1 reference

19 September 2017

Steven Boeynaems

1

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19 September 2017

Elke Bogaert

2

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19 September 2017

Albert Konijnenberg

4

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19 September 2017

Evy Timmerman

5

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19 September 2017

Alex Volkov

6

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19 September 2017

Mainak Guharoy

7

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19 September 2017

Mathias De Decker

8

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19 September 2017

Tom Jaspers

9

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19 September 2017

Veronica H Ryan

10

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19 September 2017

Abigail M Janke

11

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19 September 2017

Pieter Baatsen

12

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19 September 2017

Thomas Vercruysse

13

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19 September 2017

Regina-Maria Kolaitis

14

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19 September 2017

Nancy Kedersha

17

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19 September 2017

Paul Anderson

18

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19 September 2017

Francis Impens

19

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19 September 2017

Frederic Rousseau

22

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19 September 2017

Peter Tompa

26

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19 September 2017

1 March 2017

1 reference

full work available at URL

19 September 2017

http://eprints.whiterose.ac.uk/114006/

content deliverer

White Rose Research Online

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

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published in

Molecular Cell

1 reference

19 September 2017

65

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19 September 2017

1044-1055.e5

1 reference

19 September 2017

6

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describes a project that uses

19 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5364369/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers

1 reference

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Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

22 September 2017

1 reference

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Distinct stages in stress granule assembly and disassembly

22 September 2017

1 reference

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Inside out: the role of nucleocytoplasmic transport in ALS and FTLD

22 September 2017

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The principle of conformational signaling

22 September 2017

1 reference

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Phase Separation: Linking Cellular Compartmentalization to Disease.

22 September 2017

1 reference

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G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits

22 September 2017

1 reference

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Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

22 September 2017

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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.

22 September 2017

1 reference

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Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.

22 September 2017

1 reference

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ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

22 September 2017

1 reference

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An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

22 September 2017

1 reference

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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

22 September 2017

1 reference

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RNA Controls PolyQ Protein Phase Transitions.

22 September 2017

1 reference

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Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Adsorption of polyelectrolytes to like-charged substrates induced by multivalent counterions as exemplified by poly(styrene sulfonate) and silica

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

State of play in amyotrophic lateral sclerosis genetics

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

RNA seeds higher-order assembly of FUS protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Stress granules and cell signaling: more than just a passing phase?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Altered ribostasis: RNA-protein granules in degenerative disorders

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Defining the RGG/RG motif

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Hydrogen peroxide induces stress granule formation independent of eIF2α phosphorylation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Extrinsic fluorescent dyes as tools for protein characterization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Nucleolar proteome dynamics

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

Germline P granules are liquid droplets that localize by controlled dissolution/condensation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364369

10.1016/J.MOLCEL.2017.02.013

2 December 2018

Identifiers

DOI

1 reference

10.1016/J.MOLCEL.2017.02.013

19 September 2017

0 references

CORE ID

159332708

0 references

Dimensions Publication ID

1084096566

0 references

Microsoft Academic ID

0 references

1 reference

19 September 2017

1 reference