Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin (Q40272327)

19 September 2017

title

Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin (English)

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19 September 2017

Mathew Njoroge

6

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Lubbe Wiesner

object named as

Lubbe Wiesner

8

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Kelly Chibale

9

object named as

Kelly Chibale

1 reference

19 September 2017

5

Christel Brunschwig

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19 September 2017

7

Nina Lawrence

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19 September 2017

Sandra Bowles

1

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19 September 2017

Elizabeth Joubert

2

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19 September 2017

Dalene de Beer

3

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19 September 2017

Johan Louw

4

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19 September 2017

Christo Muller

10

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19 September 2017

language of work or name

English

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publication date

30 March 2017

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19 September 2017

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19 September 2017

volume

22

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19 September 2017

issue

4

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Creative Commons Attribution 4.0 International

19 September 2017

copyright license

start time

30 March 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome.

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The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans

21 January 2018

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Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas.

21 January 2018

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The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.

21 January 2018

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The Occurrence, Fate and Biological Activities of C-glycosyl Flavonoids in the Human Diet.

21 January 2018

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Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice

21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice

21 January 2018

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Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects

21 January 2018

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Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode

21 January 2018

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Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).

21 January 2018

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Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium.

21 January 2018

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Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential.

21 January 2018

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Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside

21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES22040554

In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity

21 January 2018

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Human sulfotransferases and their role in chemical metabolism.

21 January 2018

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Application of method suitability for drug permeability classification

21 January 2018

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Paracellular drug absorption enhancement through tight junction modulation

21 January 2018

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Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

21 January 2018

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Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

21 January 2018

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Multifunctional strands in tight junctions

21 January 2018

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Occludin: a novel integral membrane protein localizing at tight junctions

21 January 2018

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Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

21 January 2018

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Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity.

21 January 2018

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Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

21 January 2018

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Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers.

21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Transport of aspalathin, a Rooibos tea flavonoid, across the skin and intestinal epithelium.

21 January 2018

1 reference

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Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Anti-inflammatory Effects of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) In Vitro and In Vivo.

21 January 2018

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Concise and scalable synthesis of aspalathin, a powerful plasma sugar-lowering natural product

21 January 2018

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Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: sample loading and compound stability considerations.

21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

21 January 2018

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A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES22040554

In Vitro Study of UGT Metabolism and Permeability of Orientin and Isoorientin, Two Active flavonoid C-glycosides

21 January 2018

1 reference

12 December 2020

Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

1 reference

12 December 2020

Phase II drug metabolizing enzymes

1 reference

12 December 2020

Shapes of membrane permeability-lipophilicity curves: extension of theoretical models with an aqueous pore pathway.

1 reference

12 December 2020

Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations

1 reference

12 December 2020

Phenolic contribution of South African herbal teas to a healthy diet

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12 December 2020

Small bowel review: Part II

1 reference

12 December 2020

Assessment of small intestinal permeability using 1H-NMR spectroscopy.

1 reference

12 December 2020

Caco-2 cells and Biopharmaceutics Classification System (BCS) for prediction of transepithelial transport of xenobiotics (model drug: caffeine).

1 reference

12 December 2020

10.3390/MOLECULES22040554

Identifiers

DOI

1 reference

19 September 2017

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1 reference