Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. (Q40221101)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

20 December 2019

main subject

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GOA release 2020-03-11

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Andy Y Shih

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Heidi Erb

2

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20 December 2019

Xiaojian Sun

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Shigenobu Toda

4

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20 December 2019

Peter W Kalivas

5

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20 December 2019

Timothy H Murphy

6

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20 December 2019

language of work or name

English

0 references

publication date

1 October 2006

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20 December 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

26

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

10514-10523

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20 December 2019

issue

41

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Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

20 December 2019

cites work

1 reference

12 December 2020

Glutathione levels in primary glial cultures: monochlorobimane provides evidence of cell type-specific distribution

1 reference

12 December 2020

Oxidative stress-inducible proteins in macrophages

1 reference

12 December 2020

Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange

1 reference

12 December 2020

Astrocytes provide cysteine to neurons by releasing glutathione

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12 December 2020

Characterization of cystine uptake in cultured astrocytes

1 reference

12 December 2020

Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species

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12 December 2020

CSF amino acids and plasma-CSF amino acid ratios in adults

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12 December 2020

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

1 reference

12 December 2020

Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate

1 reference

12 December 2020

xCt cystine transporter expression in HEK293 cells: pharmacology and localization

1 reference

12 December 2020

1 reference

12 December 2020

The uptake of cysteine in cultured primary astrocytes and neurons

1 reference

12 December 2020

Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

1 reference

12 December 2020

Dibutyryl-cAMP (dbcAMP) up-regulates astrocytic chloride-dependent L-[3H]glutamate transport and expression of both system xc(-) subunits

1 reference

12 December 2020

Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.

1 reference

12 December 2020

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

1 reference

12 December 2020

Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells

1 reference

12 December 2020

Cerebral cystine uptake: a tale of two transporters

1 reference

12 December 2020

Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.

1 reference

12 December 2020

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

1 reference

12 December 2020

The effects of dietary sulfur amino acid deficiency on rat brain glutathione concentration and neural damage in global hemispheric hypoxia-ischemia

1 reference

12 December 2020

The consequences of methylmercury exposure on interactive functions between astrocytes and neurons

1 reference

12 December 2020

The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

1 reference

12 December 2020

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

1 reference

12 December 2020

Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.

1 reference

12 December 2020

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

1 reference

12 December 2020

Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress

1 reference

12 December 2020

Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine

1 reference

12 December 2020

Homer proteins regulate sensitivity to cocaine

1 reference

12 December 2020

Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats

1 reference

12 December 2020

Coordinate regulation of glutathione metabolism in astrocytes by Nrf2.

1 reference

12 December 2020

Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors

1 reference

12 December 2020

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

1 reference

12 December 2020

Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

1 reference

12 December 2020

Inhibition of cystine uptake disrupts the growth of primary brain tumors

1 reference

12 December 2020

Redox imbalance in cystine/glutamate transporter-deficient mice

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12 December 2020

A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.

1 reference

12 December 2020

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

1 reference

12 December 2020

Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum

1 reference

12 December 2020

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers

1 reference

12 December 2020

Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface.

1 reference

12 December 2020

Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity

1 reference

12 December 2020

Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress

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12 December 2020

Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes.

1 reference

12 December 2020

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1 reference

12 December 2020

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

1 reference

12 December 2020

L-cyst(e)ine requirements of malignant cells and progress toward depletion therapy

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12 December 2020

The free amino acids in human cerebrospinal fluid

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12 December 2020

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12 December 2020

Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension

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12 December 2020

Oxidative stress induces apoptosis in embryonic cortical neurons.

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12 December 2020

Substrates for neural metabolism of xenobiotics in adult and developing brain.

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12 December 2020

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons

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12 December 2020

Maintenance of neuronal glutathione by glial cells

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12 December 2020

Glutathione efflux from cultured astrocytes

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12 December 2020

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1 reference

12 December 2020

Construction of adenovirus vectors through Cre-lox recombination

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12 December 2020

Requirement for cGMP in nerve cell death caused by glutathione depletion

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12 December 2020

Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine.

1 reference

12 December 2020

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

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12 December 2020

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

1 reference

12 December 2020

Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange.

1 reference

12 December 2020

10.1523/JNEUROSCI.3178-06.2006

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17035536%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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20 December 2019

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