Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. (Q38327788)

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10 January 2020

title

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo (English)

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10 January 2020

2

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10 January 2020

author name string

Andy Y Shih

1

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10 January 2020

Vilte Barakauskas

3

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10 January 2020

Heidi Erb

4

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10 January 2020

Lei Jiang

5

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10 January 2020

Ping Li

6

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10 January 2020

Timothy H Murphy

7

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language of work or name

English

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publication date

19 April 2005

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Journal of Biological Chemistry

10 January 2020

number of pages

12

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based on heuristic

inferred from page(s)

published in

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volume

280

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10 January 2020

page(s)

22925-22936

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issue

24

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

10 January 2020

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

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Enhanced NAD(P)H:Quinone Reductase Activity Prevents Glutamate Toxicity Produced by Oxidative Stress

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21 January 2018

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Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

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Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase

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Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

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21 January 2018

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21 January 2018

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21 January 2018

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Astrocyte-enhanced neuronal survival is mediated by scavenging of extracellular reactive oxygen species.

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21 January 2018

Identifiers

DOI

10.1074/JBC.M414635200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15840590%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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