Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein. (Q40181511)

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24 December 2019

title

Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein (English)

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24 December 2019

3

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24 December 2019

author name string

Chi-Chen Lin

1

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24 December 2019

Cheng-Fen Tu

2

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24 December 2019

Ming-Chuan Chen

4

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24 December 2019

Wan-Jung Hsieh

5

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24 December 2019

Wen-Chang Chang

6

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Wen-Tsang Chang

7

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24 December 2019

Ming-Derg Lai

8

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24 December 2019

publication date

1 February 2007

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24 December 2019

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24 December 2019

volume

15

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24 December 2019

issue

2

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24 December 2019

page(s)

404-410

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

24 December 2019

cites work

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

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Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion

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Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.

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Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation

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Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

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Degradation of cell proteins and the generation of MHC class I-presented peptides

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Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases

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Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

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Met, metastasis, motility and more

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Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines

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7 January 2021

Identification of C-met oncogene as a broadly expressed tumor-associated antigen recognized by cytotoxic T-lymphocytes

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Phase I clinical trial of a HER-2/neu peptide (E75) vaccine for the prevention of prostate-specific antigen recurrence in high-risk prostate cancer patients

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DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice

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Complementary antitumor immunity induced by plasmid DNA encoding secreted and cytoplasmic human ErbB-2.

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Accelerated HER-2 degradation enhances ovarian tumor recognition by CTL. Implications for tumor immunogenicity

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7 January 2021

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

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7 January 2021

Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.

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7 January 2021

Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice

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7 January 2021

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

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7 January 2021

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Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors

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7 January 2021

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Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300014

1 reference

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24 December 2019

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