Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation (Q40177813)

18 September 2017

title

Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation (English)

1 reference

18 September 2017

main subject

systemic mastocytosis

1 reference

aggressive systemic mastocytosis

inferred from title

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Nami Nakagomi

1

1 reference

18 September 2017

Seiichi Hirota

series ordinal

2

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18 September 2017

publication date

29 January 2007

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18 September 2017

published in

Laboratory Investigation

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18 September 2017

volume

87

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18 September 2017

issue

4

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18 September 2017

page(s)

365-371

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700524

18 September 2017

exact match

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cites work

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Diagnostic criteria and classification of mastocytosis: a consensus proposal

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The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

21 January 2018

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Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

21 January 2018

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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

1 reference

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

21 January 2018

1 reference

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Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

21 January 2018

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

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Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior

21 January 2018

1 reference

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A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

21 January 2018

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KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors

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Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours

21 January 2018

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c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors

21 January 2018

1 reference

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

21 January 2018

1 reference

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Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

21 January 2018

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Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

21 January 2018

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Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis

21 January 2018

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KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)

21 January 2018

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Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha

21 January 2018

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STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity

21 January 2018

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Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.

21 January 2018

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Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

21 January 2018

1 reference

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Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970.

21 January 2018

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In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit.

21 January 2018

1 reference

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10.1038/LABINVEST.3700524

21 January 2018

Identifiers

DOI

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30 July 2022

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Dimensions Publication ID

1051955358

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30 July 2022

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30 July 2022