STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity (Q40787487)

23 September 2017

STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity (English)

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23 September 2017

Ning ZQ

1

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23 September 2017

Li J

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2

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23 September 2017

McGuinness M

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3

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23 September 2017

Arceci RJ

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4

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23 September 2017

language of work or name

English

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publication date

1 July 2001

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23 September 2017

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23 September 2017

20

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23 September 2017

4528-4536

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23 September 2017

33

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204590

23 September 2017

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Effects of mutant c-Kit in early myeloid cells

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The role of STATs in transcriptional control and their impact on cellular function

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Stat3 activation is required for cellular transformation by v-src

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Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts

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Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase: effect of receptor density and ligand-requirement

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

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STATs and gene regulation

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The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

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Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

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STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

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The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

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Activating mutations for the met tyrosine kinase receptor in human cancer

21 January 2018

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STAT3 is required for the gp130-mediated full activation of the c-myc gene

21 January 2018

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Early signaling pathways activated by c-Kit in hematopoietic cells

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Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

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Role of aspartic acid 814 in the function and expression of c-kit receptor tyrosine kinase

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

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Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.

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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

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Activating c-kit gene mutations in human germ cell tumors

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Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

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Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3

21 January 2018

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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Signal transduction by receptors with tyrosine kinase activity

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Identification of a ligand for the c-kit proto-oncogene

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Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D.

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Retroviral vector targeting human cells via c-Kit-stem cell factor interaction

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

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Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

21 January 2018

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Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

21 January 2018

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Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204590

inferred from DOI database lookup

7 January 2021

based on heuristic

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204590

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1204590

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Dimensions Publication ID

23 September 2017

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