Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling (Q40168518)

18 September 2017

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling (English)

1 reference

18 September 2017

12

1 reference

18 September 2017

Maria Cristina Gagliani

Maria Cristina Gagliani

6

0 references

Raffaella Magrassi

Raffaella Magrassi

5

0 references

Emanuela Repetto

Emanuela Repetto

3

0 references

Claudio Russo

Claudio Russo

13

0 references

Tommaso Russo

Tommaso Russo

11

0 references

Carlo Tacchetti

Carlo Tacchetti

10

0 references

Tullio Florio

Tullio Florio

8

0 references

author name string

Mario Nizzari

1

1 reference

18 September 2017

Valentina Venezia

2

1 reference

18 September 2017

Valentina Caorsi

4

1 reference

18 September 2017

Pia Carlo

7

1 reference

18 September 2017

Gennaro Schettini

9

1 reference

18 September 2017

language of work or name

English

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publication date

21 February 2007

1 reference

Journal of Biological Chemistry

18 September 2017

1 reference

18 September 2017

282

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18 September 2017

18

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18 September 2017

13833-13844

1 reference

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alzheimer disease therapy: can the amyloid cascade be halted?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Involvement of presenilins in cell-survival signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin 1: more than just gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Protein phosphorylation and APP metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Centrosome control of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alsin is partially associated with centrosome in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

γ-Tubulin is a highly conserved component of the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Subcellular localization of presenilins during mouse preimplantation development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Ligand-dependent G protein coupling function of amyloid transmembrane precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Centrosome amplification, chromosome instability and cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Rab11 regulates recycling through the pericentriolar recycling endosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610146200

1 reference

18 September 2017

1 reference