Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. (Q40158925)

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27 December 2019

title

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation (English)

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27 December 2019

4

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27 December 2019

Egon Ogris

5

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27 December 2019

Steven R. Lentz

7

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27 December 2019

author name string

Estelle Sontag

1

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27 December 2019

Viyada Nunbhakdi-Craig

2

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27 December 2019

Jean-Marie Sontag

3

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27 December 2019

Sanjana Dayal

6

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27 December 2019

Erland Arning

8

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27 December 2019

Teodoro Bottiglieri

9

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language of work or name

English

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publication date

1 March 2007

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27 December 2019

published in

Journal of Neuroscience

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27 December 2019

volume

27

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27 December 2019

page(s)

2751-2759

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27 December 2019

issue

11

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

27 December 2019

cites work

1 reference

12 December 2020

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

1 reference

12 December 2020

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

1 reference

12 December 2020

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

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12 December 2020

Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice

1 reference

12 December 2020

Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations

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12 December 2020

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

1 reference

12 December 2020

Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen

1 reference

12 December 2020

Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons

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12 December 2020

Protein phosphatase 2A: the Trojan Horse of cellular signaling

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12 December 2020

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

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12 December 2020

Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines

1 reference

12 December 2020

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

1 reference

12 December 2020

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease

1 reference

12 December 2020

Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

1 reference

12 December 2020

Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage

1 reference

12 December 2020

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

12 December 2020

Homocysteine and Alzheimer's disease

1 reference

12 December 2020

Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5.

1 reference

12 December 2020

Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

1 reference

12 December 2020

APP processing is regulated by cytoplasmic phosphorylation

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12 December 2020

Protein phosphorylation and APP metabolism

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12 December 2020

Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function

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12 December 2020

Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

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12 December 2020

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

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12 December 2020

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.

1 reference

12 December 2020

Tau phosphorylation: physiological and pathological consequences

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12 December 2020

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

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12 December 2020

beta-Secretase, APP and Abeta in Alzheimer's disease.

1 reference

12 December 2020

The non-amyloidogenic pathway: structure and function of alpha-secretases

1 reference

12 December 2020

The role of cystathionine beta-synthase in homocysteine metabolism

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12 December 2020

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

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12 December 2020

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

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12 December 2020

Sodium azide and 2-deoxy-D-glucose-induced cellular stress affects phosphorylation-dependent AbetaPP processing

1 reference

12 December 2020

The transmethylation cycle in the brain of Alzheimer patients

1 reference

12 December 2020

Homocysteine: overview of biochemistry, molecular biology, and role in disease processes

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12 December 2020

Homocysteine and folate as risk factors for dementia and Alzheimer disease

1 reference

12 December 2020

Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study

1 reference

12 December 2020

Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease

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12 December 2020

Sialylation enhances the secretion of neurotoxic amyloid-beta peptides

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12 December 2020

BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration

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12 December 2020

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels

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12 December 2020

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

1 reference

12 December 2020

CSF S-adenosylmethionine in neuropsychiatric disorders.

1 reference

12 December 2020

APP processing and the APP-KPI domain involvement in the amyloid cascade.

1 reference

12 December 2020

Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.

1 reference

12 December 2020

Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum

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12 December 2020

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

12 December 2020

Isocratic high performance liquid chromatographic analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide

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12 December 2020

The effect of storage on rat tissues and human plasma amino acid levels determined by HPLC.

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12 December 2020

Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.

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12 December 2020

Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease

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12 December 2020

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

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12 December 2020

Phosphorylation of tau, Abeta-formation, and apoptosis after in vivo inhibition of PP-1 and PP-2A.

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12 December 2020

Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells.

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12 December 2020

Autoregulation of protein phosphatase type 2A expression

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12 December 2020

10.1523/JNEUROSCI.3316-06.2007

Identifiers

DOI

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27 December 2019

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Fatcat

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