The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase (Q40105885)

17 September 2017

The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase (English)

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17 September 2017

6

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17 September 2017

Roya M Dayam

1

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17 September 2017

Chun X Sun

2

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17 September 2017

Christopher H Choy

3

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17 September 2017

Gemma Mancuso

4

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17 September 2017

Michael Glogauer

5

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17 September 2017

language of work or name

English

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publication date

4 August 2017

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17 September 2017

Journal of Immunology

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17 September 2017

199

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17 September 2017

2096-2105

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17 September 2017

6

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Phagosome dynamics during phagocytosis by neutrophils

17 September 2017

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The multifaceted functions of neutrophils

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phagocytosis by neutrophils

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Granule protein processing and regulated secretion in neutrophils

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Kinetics of fusion of the cytoplasmic granules with phagocytic vacuoles in human polymorphonuclear leukocytes. Biochemical and morphological studies

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The multifaceted role of PIP2 in leukocyte biology.

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphoinositides: tiny lipids with giant impact on cell regulation

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphoinositides in cell regulation and membrane dynamics

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Membrane phospholipid metabolism during phagocytosis in human neutrophils

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve regulation of endosome-linked pathways

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantifying Phagocytosis by Immunofluorescence and Microscopy.

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantitative Immunofluorescence to Study Phagosome Maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Lysosome-related organelles

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve negatively regulates exocytosis in neurosecretory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Membrane repair: Ca(2+)-elicited lysosomal exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The role of Rac1 and Rac2 in bacterial killing

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac2 is critical for neutrophil primary granule exocytosis.

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Regulation of innate immunity by Rho GTPases

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

P-Rex1 regulates neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

ATF3 is a novel regulator of mouse neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A targeted mass spectrometric analysis of phosphatidylinositol phosphate species

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1601466

1 reference

17 September 2017

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