PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. (Q38993815)

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18 March 2020

title

PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1 (English)

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18 March 2020

6

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18 March 2020

Tobias Zech

3

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18 March 2020

Jørgen Wesche

8

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18 March 2020

2

Ellen M Haugsten

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18 March 2020

author name string

Angela Oppelt

1

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18 March 2020

Håvard E Danielsen

4

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18 March 2020

Anita Sveen

5

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18 March 2020

Rolf I Skotheim

7

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18 March 2020

language of work or name

English

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publication date

1 August 2014

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18 March 2020

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18 March 2020

volume

461

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issue

3

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page(s)

383-390

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Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

18 March 2020

cites work

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Phosphatidylinositol 5-phosphate is a second messenger important for cell migration.

21 January 2018

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Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve

21 January 2018

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The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness

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The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus

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A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

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The consensus coding sequences of human breast and colorectal cancers

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Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors

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Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability

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A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

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Rho GTPases in cancer cell biology

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Rac activation and inactivation control plasticity of tumor cell movement

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Comparison of Affymetrix data normalization methods using 6,926 experiments across five array generations

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Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

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A nuclear export sequence located on a beta-strand in fibroblast growth factor-1.

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

21 January 2018

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Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound

21 January 2018

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Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

21 January 2018

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Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity

21 January 2018

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Monitoring live cell viability: Comparative study of fluorescence, oblique incidence reflection and phase contrast microscopy imaging techniques.

21 January 2018

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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

21 January 2018

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Cell migration: a physically integrated molecular process

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Rho GTPases and the actin cytoskeleton

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Cell migration: Rho GTPases lead the way

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

21 January 2018

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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

21 January 2018

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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

21 January 2018

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Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

21 January 2018

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A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides

21 January 2018

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

21 January 2018

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Functional redundancy in the myotubularin family

21 January 2018

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Role of Rho GTPases and their regulators in cancer progression

21 January 2018

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PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20140132

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24840251%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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