The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis. (Q40066489)

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scientific article published in October 2007

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English	The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.	scientific article published in October 2007

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9 January 2020

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis (English)

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9 January 2020

apoptotic process

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Miguel F Segura

1

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9 January 2020

Carme Solé Vendrell

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9 January 2020

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9 January 2020

Raffaella Gozzelino

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9 January 2020

Jose R. Bayascas

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9 January 2020

José Rodríguez-Alvarez

11

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9 January 2020

Victor J. Yuste

13

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9 January 2020

Joan X. Comella

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9 January 2020

author name string

Rana S Moubarak

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9 January 2020

M Jose Perez-Garcia

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9 January 2020

Victoria Iglesias

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9 January 2020

Nuria Llecha

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9 January 2020

Eduardo Soriano

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9 January 2020

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1 October 2007

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9 January 2020

Journal of Neuroscience

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42

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9 January 2020

11228-11241

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9 January 2020

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB

1 reference

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12 December 2020

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Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge

1 reference

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12 December 2020

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A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes

1 reference

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12 December 2020

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CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.

1 reference

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12 December 2020

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Apoptosis: Silencing the death receptors

1 reference

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12 December 2020

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FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

1 reference

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12 December 2020

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Active killing of neurons during development and following stress: a role for p75(NTR) and Fas?

1 reference

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12 December 2020

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Mitochondria as the central control point of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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The absence of oligonucleosomal DNA fragmentation during apoptosis of IMR-5 neuroblastoma cells: disappearance of the caspase-activated DNase.

1 reference

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12 December 2020

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Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

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FGF induces a switch in death receptor pathways in neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

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Fas ligand mRNA expression in the mouse central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

1 reference

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12 December 2020

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Fatal shift of signal transduction is an integral part of neuronal differentiation: JNKs realize TNFalpha-mediated apoptosis in neuronlike, but not naive, PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Comparison of neuronal density and subfield sizes in the hippocampus of CD95L-deficient (gld), CD95-deficient (lpr) and nondeficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

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Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

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Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas engagement induces neurite growth through ERK activation and p35 upregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

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Neurotrophins and their receptors: a convergence point for many signalling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

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Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive expression of p55TNFR mRNA and mitogen-specific up-regulation of TNF alpha and p75TNFR mRNA in mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life and death decisions: the role of the IAPs in modulating programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-FLIP-L recombinant adeno-associated virus vector infection prevents Fas-mediated but not nerve growth factor withdrawal-mediated cell death in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Fas-mediated apoptosis after traumatic spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Instant decisions: transcription-independent control of death-receptor-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of eukaryotic expression technology in the functional analysis of cloned genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of death receptor signals by cellular FLIP

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of fas death signals by FLIPs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of fas antigen in the normal mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of constitutive TNF receptor 1 signaling by silencer of death domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and isolation of proteolytically modified nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17942717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3462-07.2007

1 reference

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9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942717%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942717%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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