Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion (Q40044903)

16 September 2017

Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion (English)

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16 September 2017

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J C Peak

1

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16 September 2017

N P Jones

2

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16 September 2017

S Hobbs

3

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16 September 2017

M Katan

4

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16 September 2017

S A Eccles

5

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16 September 2017

language of work or name

English

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publication date

26 November 2007

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16 September 2017

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27

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20

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16 September 2017

2823-2832

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210954

16 September 2017

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The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

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Linking Rap to cell adhesion

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Phospholipase C-gamma1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation

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C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells

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Transformation suppressor activity of C3G is independent of its CDC25-homology domain.

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

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Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.

21 January 2018

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Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.

21 January 2018

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PLCgamma1 is essential for early events in integrin signalling required for cell motility

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Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

21 January 2018

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DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling

21 January 2018

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Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion

21 January 2018

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Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

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Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation

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Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

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Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases

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A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

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Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion.

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Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

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Focal adhesion kinase promotes phospholipase C-gamma1 activity.

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Structure, function, and control of phosphoinositide-specific phospholipase C

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inferred from DOI database lookup

7 January 2021

based on heuristic

Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210954

inferred from DOI database lookup

7 January 2021

based on heuristic

PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210954

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210954

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Dimensions Publication ID

16 September 2017

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