mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. (Q40040866)

16 September 2017

mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. (English)

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16 September 2017

Franklin C Harwood

1

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16 September 2017

Lili Shu

series ordinal

2

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16 September 2017

Peter J Houghton

series ordinal

3

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16 September 2017

language of work or name

English

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publication date

4 December 2007

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

5

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16 September 2017

2575-2585

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16 September 2017

The two TORCs and Akt.

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

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Signaling by target of rapamycin proteins in cell growth control

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The TOR pathway: a target for cancer therapy

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Tor signalling in bugs, brain and brawn

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TOR, a central controller of cell growth

21 January 2018

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TOR signaling in growth and metabolism

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Defining the role of mTOR in cancer

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

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mTOR, translational control and human disease.

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

21 January 2018

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Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast

21 January 2018

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B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

21 January 2018

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Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein

21 January 2018

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Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits

21 January 2018

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Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity

21 January 2018

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Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

21 January 2018

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The in vitro influence of eight hormones and growth factors on the proliferation of eight sarcoma cell lines

21 January 2018

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Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties

21 January 2018

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Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

21 January 2018

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Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases

21 January 2018

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Regulation of protein kinase cascades by protein phosphatase 2A.

21 January 2018

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Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

21 January 2018

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Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells

21 January 2018

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Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

21 January 2018

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Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha

21 January 2018

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Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression

21 January 2018

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

21 January 2018

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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

21 January 2018

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Dephosphorylation of Ser-259 regulates Raf-1 membrane association

21 January 2018

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The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

21 January 2018

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Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities

21 January 2018

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

21 January 2018

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Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

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21 January 2018

Identifiers

DOI

10.1074/JBC.M706173200

1 reference

16 September 2017

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