Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim. (Q39977634)

16 September 2017

Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim. (English)

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16 September 2017

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Seamus J Martin

3

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author name string

Clare Sheridan

series ordinal

1

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PubMed ID

18508762

16 September 2017

Gabriela Brumatti

series ordinal

2

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PubMed ID

18508762

16 September 2017

language of work or name

English

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publication date

27 May 2008

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

32

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16 September 2017

22128-22135

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https://api.crossref.org/works/10.1074%2FJBC.M800271200

16 September 2017

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Determinants of BRAF mutations in primary melanomas

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BRAF as a potential therapeutic target in melanoma and other malignancies

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

21 January 2018

1 reference

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Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

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Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

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Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

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An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

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Apoptotic pathways: ten minutes to dead

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The role of BH3-only proteins in the immune system

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Apoptosomes: protease activation platforms to die from

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BH3-Only proteins-essential initiators of apoptotic cell death

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

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The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

21 January 2018

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B-RAF is a therapeutic target in melanoma

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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BRAF mutation predicts sensitivity to MEK inhibition

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M800271200

1 reference

16 September 2017

1 reference

PubMed ID

18508762