The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (Q39948991)

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English	The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 September 2017

The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (English)

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Europe PubMed Central

PubMed publication ID

15 September 2017

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Andrew Reay Mackay

10

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Europe PubMed Central

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15 September 2017

author name string

A R Farina

1

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15 September 2017

A Tacconelli

2

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15 September 2017

L Cappabianca

3

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15 September 2017

G Cea

4

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15 September 2017

A Chioda

5

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15 September 2017

A Romanelli

6

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15 September 2017

S Pensato

7

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15 September 2017

C Pedone

8

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15 September 2017

A Gulino

9

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15 September 2017

language of work or name

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publication date

7 September 2009

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15 September 2017

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15 September 2017

28

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15 September 2017

46

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Europe PubMed Central

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15 September 2017

4075-4094

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Europe PubMed Central

PubMed publication ID

15 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2009.256

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Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).

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21 January 2018

Molecular and biochemical characterization of the human trk proto-oncogene

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21 January 2018

Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA.

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Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro

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Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

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21 January 2018

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84)

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21 January 2018

TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor

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Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study

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Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases

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Hsp90 Recognizes a Common Surface on Client Kinases

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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31 March 2020

Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation

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HSP90: a rising star on the horizon of anticancer targets

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Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells

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31 March 2020

Profiling of nuclear extract proteins from human neuroblastoma cell lines: the search for fingerprints.

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31 March 2020

The ATPase cycle of the endoplasmic chaperone Grp94.

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Chaperone proteins and brain tumors: potential targets and possible therapeutics

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31 March 2020

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Molecular kinetics of nerve growth factor receptor trafficking and activation

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells.

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

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Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

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The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.

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Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Trk receptor tyrosine kinases: a bridge between cancer and neural development

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Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives

1 reference

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Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons

1 reference

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Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Coordinated ATP hydrolysis by the Hsp90 dimer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Adenosine nucleotides and the regulation of GRP94-client protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1 reference

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Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Endoplasmic reticulum stress responses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.256

31 March 2020

Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells

1 reference

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A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.

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Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system

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Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma

1 reference

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Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context.

1 reference

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Geldanamycin treatment ameliorates the response to LPS in murine macrophages by decreasing CD14 surface expression

1 reference

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TrkA glycosylation regulates receptor localization and activity

1 reference

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A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study

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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

1 reference

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

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Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells

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ErbB2 degradation mediated by the co-chaperone protein CHIP

1 reference

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31 March 2020

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10.1038/ONC.2009.256

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Europe PubMed Central

PubMed publication ID

15 September 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

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