Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. (Q39943159)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772195%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons (English)

1 reference

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13 January 2020

1 reference

1

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13 January 2020

Géraldine Liot

4

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13 January 2020

Sandrine Humbert

5

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13 January 2020

Frédéric Saudou

6

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13 January 2020

author name string

Emilie Colin

2

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13 January 2020

Hélène Rangone

3

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13 January 2020

publication date

4 September 2008

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13 January 2020

published in

Human Molecular Genetics

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13 January 2020

volume

17

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13 January 2020

issue

24

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13 January 2020

page(s)

3837-3846

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Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

13 January 2020

cites work

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

21 January 2018

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Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

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Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons

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Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

21 January 2018

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Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

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Anterograde transport of brain-derived neurotrophic factor and its role in the brain.

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Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

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Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

21 January 2018

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Akt is altered in an animal model of Huntington's disease and in patients

21 January 2018

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Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

21 January 2018

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

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Light chain-dependent regulation of Kinesin's interaction with microtubules

21 January 2018

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Influence of the centrosome on the structure of nucleated microtubules

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A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity

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Microtubule binding proteins CLIP-170, EB1, and p150Glued form distinct plus-end complexes

21 January 2018

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Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

21 January 2018

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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

21 January 2018

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Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

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