Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase (Q39909069)

15 September 2017

title

Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase (English)

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15 September 2017

7

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15 September 2017

Andrea Ballabeni

1

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15 September 2017

Raffaella Zamponi

2

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15 September 2017

Greta Caprara

3

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15 September 2017

Marina Melixetian

4

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15 September 2017

Sergio Bossi

5

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15 September 2017

Laura Masiero

6

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15 September 2017

language of work or name

English

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publication date

3 December 2008

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Journal of Biological Chemistry

15 September 2017

published in

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15 September 2017

volume

284

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15 September 2017

issue

5

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15 September 2017

page(s)

3028-3036

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The Cdc7 protein kinase is required for origin firing during S phase

15 September 2017

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Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase

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CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication

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A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

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21 January 2018

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

21 January 2018

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Control of DNA replication and chromosome ploidy by geminin and cyclin A

21 January 2018

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

21 January 2018

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A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus

21 January 2018

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A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

21 January 2018

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21 January 2018

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The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

21 January 2018

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21 January 2018

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21 January 2018

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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

21 January 2018

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

21 January 2018

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

21 January 2018

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Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex

21 January 2018

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An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

21 January 2018

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21 January 2018

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21 January 2018

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Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity

21 January 2018

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21 January 2018

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A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition

21 January 2018

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PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

21 January 2018

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Geminin-Cdt1 balance is critical for genetic stability

21 January 2018

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

21 January 2018

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Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803609200

1 reference

15 September 2017

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