A rapid protocol for construction and production of high-capacity adenoviral vectors (Q39859960)

15 September 2017

A rapid protocol for construction and production of high-capacity adenoviral vectors (English)

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15 September 2017

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Lorenz Jager

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15 September 2017

Martin A Hausl

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15 September 2017

Christina Rauschhuber

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15 September 2017

Nicola M Wolf

4

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15 September 2017

Mark A Kay

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15 September 2017

Anja Ehrhardt

6

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15 September 2017

language of work or name

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1 January 2009

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15 September 2017

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547-564

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https://scigraph.springernature.com/pub.10.1038/nprot.2009.4

15 September 2017

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Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis

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Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

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Successful compensation for dystrophin deficiency by a helper-dependent adenovirus expressing full-length utrophin

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Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin

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Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A

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Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model

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Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectors

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Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia.

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Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector

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Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector

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Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus

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Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia

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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector

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A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia

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A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo

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Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy

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IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.

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Emerging adenoviral vectors for stable correction of genetic disorders

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Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

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Somatic integration from an adenoviral hybrid vector into a hot spot in mouse liver results in persistent transgene expression levels in vivo

21 January 2018

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Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors.

21 January 2018

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Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors

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Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells

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Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors

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Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors

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Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

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Tightly regulated gene expression in human hematopoietic stem cells after transduction with helper-dependent Ad5/35 vectors

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Efficient delivery and stable gene expression in a hematopoietic cell line using a chimeric serotype 35 fiber pseudotyped helper-dependent adenoviral vector

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Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.

21 January 2018

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Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways

21 January 2018

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Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter

21 January 2018

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Transposon-assisted cloning and traceless mutagenesis of adenoviruses: Development of a novel vector based on species D.

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Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

21 January 2018

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Development of a FLP/frt system for generating helper-dependent adenoviral vectors

21 January 2018

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Development of a suspension serum-free helper-dependent adenovirus production system and assessment of co-infection conditions

21 January 2018

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A Cre-expressing cell line and an E1/E2a double-deleted virus for preparation of helper-dependent adenovirus vector

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Optimization of the helper-dependent adenovirus system for production and potency in vivo

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Exploring gene-deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice

21 January 2018

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Improved system for helper-dependent adenoviral vector production

21 January 2018

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System for efficient helper-dependent minimal adenovirus construction and rescue

21 January 2018

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A convenient plasmid system for construction of helper-dependent adenoviral vectors and its application for analysis of the breast-cancer-specific mammaglobin promoter

21 January 2018

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Generation of helper-dependent adenoviral vectors by homologous recombination

21 January 2018

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Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method

21 January 2018

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Stability of a recombinant adenoviral vector: optimization of conditions for storage, transport and delivery

21 January 2018

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Instability of adenoviral vectors during transport and its implication for clinical studies

21 January 2018

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Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.

21 January 2018

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Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference material

21 January 2018

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Replication control of autonomously replicating human sequence

21 January 2018

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Transduction of Full-length Dystrophin to Multiple Skeletal Muscles Improves Motor Performance and Life Span in Utrophin/Dystrophin Double Knockout Mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2009.4

31 March 2020

12 December 2020

Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy.

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.4

Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.4

A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging.

31 March 2020

1 reference

12 December 2020

Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase

1 reference

12 December 2020

Preparation of helper-dependent adenoviral vectors

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12 December 2020

Construction of adenovirus vectors through Cre-lox recombination

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12 December 2020

Packaging capacity and stability of human adenovirus type 5 vectors.

1 reference

12 December 2020

Development of a rapid method for the PEGylation of adenoviruses with enhanced transduction and improved stability under harsh storage conditions

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12 December 2020

Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.

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12 December 2020

Adenoviral transduction of dendritic cells

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12 December 2020

Identifiers

DOI

10.1038/NPROT.2009.4

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15 September 2017

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