MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM. (Q39858584)

15 September 2017

MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM. (English)

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15 September 2017

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lymphoblastic leukemia

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A A Rambal

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15 September 2017

Z L G Panaguiton

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15 September 2017

L Kramer

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S Grant

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H Harada

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15 September 2017

30 April 2009

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23

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10

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1744-1754

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https://scigraph.springernature.com/pub.10.1038/leu.2009.80

15 September 2017

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p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells

22 September 2017

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Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

22 September 2017

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Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance.

22 September 2017

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Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

22 September 2017

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Cell death: critical control points

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Conferring specificity on the ubiquitous Raf/MEK signalling pathway

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Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia

22 September 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

22 September 2017

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The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

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22 September 2017

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22 September 2017

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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20 August 2018

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Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies

20 August 2018

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Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

20 August 2018

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

20 August 2018

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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

20 August 2018

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Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FLEU.2009.80

Acute lymphoblastic leukemia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19404317

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19404317

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19404317

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2009.80

1 reference

15 September 2017

1 reference

15 September 2017

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