(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. (Q39852275)

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English	(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2.	scientific article

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28 January 2020

(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2 (English)

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28 January 2020

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pancreatic cancer

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based on heuristic

inferred from title

cancer cell line

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Steven J. Schwartz

5

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28 January 2020

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Yanyan Li

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28 January 2020

Tao Zhang

2

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28 January 2020

Yiqun Jiang

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28 January 2020

Hsiu-Fang Lee

4

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28 January 2020

Duxin Sun

6

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28 January 2020

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1 July 2009

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28 January 2020

Molecular Pharmaceutics

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28 January 2020

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28 January 2020

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28 January 2020

1152-1159

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28 January 2020

(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor

1 reference

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22 September 2017

The Hsp90 molecular chaperone: an open and shut case for treatment

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Development and application of Hsp90 inhibitors

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Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

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22 September 2017

Biology and management of pancreatic cancer

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Inhibitors of the heat shock response: biology and pharmacology

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A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent

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Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

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Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives

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Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.

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A proteomic snapshot of the human heat shock protein 90 interactome

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Heat shock response modulators as therapeutic tools for diseases of protein conformation

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22 September 2017

(-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

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22 September 2017

Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein

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22 September 2017

Therapeutic and diagnostic implications of Hsp90 activation

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22 September 2017

Altered states: selectively drugging the Hsp90 cancer chaperone

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Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

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Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain

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22 September 2017

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

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22 September 2017

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Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

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Two stages of cancer prevention with green tea

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based on heuristic

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Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438225

12 December 2020

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inferred from PubMed ID database lookup

Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/MP900037P

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28 January 2020

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28 January 2020

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28 January 2020

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