DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. (Q39786213)

14 September 2017

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. (English)

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14 September 2017

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E Bourke

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Helfrid Hochegger

object named as

H Hochegger

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Shunichi Takeda

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S Takeda

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author name string

J A L Brown

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14 September 2017

C G Morrison

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14 September 2017

language of work or name

English

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publication date

19 October 2009

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14 September 2017

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14 September 2017

29

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14 September 2017

4

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14 September 2017

616-624

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https://scigraph.springernature.com/pub.10.1038/onc.2009.340

14 September 2017

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Cdk2 knockout mice are viable

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DNA damage induces Chk1-dependent centrosome amplification.

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Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

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Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

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Involvement of centrosome amplification in radiation-induced mitotic catastrophe

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Centrosomes in cellular regulation

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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

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Oncogenes and tumour suppressors take on centrosomes

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Abnormal centrosome amplification in the absence of p53.

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A mechanism linking extra centrosomes to chromosomal instability

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Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

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Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

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An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

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The cyclin A1-CDK2 complex regulates DNA double-strand break repair.

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Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

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Origins and consequences of centrosome aberrations in human cancers

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

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Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine

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Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

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p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

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Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis

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Deregulated cyclin E induces chromosome instability

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Loss of p53 and centrosome hyperamplification.

31 March 2020

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Mechanism limiting centrosome duplication to once per cell cycle

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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

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Centrosome number is controlled by a centrosome-intrinsic block to reduplication

31 March 2020

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Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

31 March 2020

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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

31 March 2020

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2009.340

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Dimensions Publication ID

14 September 2017

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