Observations on screening-based research and some concerning trends in the literature (Q39769260)

14 September 2017

Observations on screening-based research and some concerning trends in the literature (English)

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14 September 2017

Jonathan B Baell

1

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14 September 2017

1 October 2010

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Future Medicinal Chemistry

14 September 2017

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14 September 2017

2

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14 September 2017

10

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14 September 2017

1529-1546

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

14 September 2017

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Electrophilicity parameters of 5-benzylidene-2,2-dimethyl[1,3]dioxane-4,6-diones (benzylidene Meldrum's acids).

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Treatment of Alzheimer's disease with clioquinol

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Efficient synthetic inhibitors of anthrax lethal factor

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Chemical probes of UDP-galactopyranose mutase

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

A broad-spectrum antiviral targeting entry of enveloped viruses

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Strategic Pooling of Compounds for High-Throughput Screening

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Prediction of 'drug-likeness'.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Naphthyl ketones: a new class of Janus kinase 3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

The art of the chemical probe

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

SYBYL line notation (SLN): a single notation to represent chemical structures, queries, reactions, and virtual libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.237

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.237

21 January 2018

Identifiers

DOI

10.4155/FMC.10.237

1 reference

14 September 2017

1 reference

PubMed ID

21426147